Chapter 165. Traumatic Brain Injury

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief2,3,
  2. Daniel D. Truong MD, FAAN Head4,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head5 and
  4. Roongroj Bhidayasiri MD, FRCP Director6,7
  1. Christopher C. Giza MD Associate Professor

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch165

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Giza, C. C. (2009) Traumatic Brain Injury, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch165

Editor Information

  1. 2

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 3

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 4

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 5

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 6

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 7

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. Neurosurgery and Pediatric Neurology, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Mattel Children's Hospital – UCLA, Los Angeles, CA, USA

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • Traumatic brain injury (TBI), any biomechanically-induced acquired brain injury;
  • TBI in spectrum from mild to severe - typically classified based on clinical signs;
  • TBI, in trimodal age distribution, with peaks in infancy, adolescence/young adulthood, and senescence;
  • recurrent mild concussions, commonly seen in sports-related settings;
  • mechanisms underlying moderate and severe TBI - varying by age and geography;
  • underlying pathophysiology of TBI - depends, to a large degree upon injury severity;
  • more severe TBI, distinct injury processes and pathology;
  • TBI hallmarks - neurological dysfunction and mental status impairment;
  • mild TBI/concussion, requiring additional diagnostic testing


This chapter contains sections titled:

  • Introduction

  • Epidemiology

  • Pathophysiology

  • Clinical features

  • Investigations

  • Treatment/management

  • Further reading