Chapter 37. Mild Cognitive Impairment

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief2,3,
  2. Daniel D. Truong MD, FAAN Head4,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head5 and
  4. Roongroj Bhidayasiri MD, FRCP Director6,7
  1. Elka Stefanova MD, PhD Associate Professor of Neurology and
  2. Vladimir Kostic MD, PhD Professor of Neurology

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch37

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Stefanova, E. and Kostic, V. (2009) Mild Cognitive Impairment, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch37

Editor Information

  1. 2

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 3

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 4

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 5

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 6

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 7

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. Institute of Neurology, School of Medicine, University of Belgrade, Belgrade, Serbia, USA

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • mild cognitive impairment (MCI);
  • MCI - age-associated memory impairment, age-associated cognitive impairment;
  • epidemiology - greater age-specific prevalence than dementia;
  • clinical features - memory complaint, age and education memory impairment;
  • investigations - brain imaging and cerebrospinal fluid (CSF) biomarkers;
  • treatment - preventing progression of cognitive and functional deficits;
  • donepezil - transient preventive effect at 1 year


This chapter contains sections titled:

  • Introduction

  • Epidemiology

  • Clinical features

  • Pathophysiology

  • Investigations

  • Treatment

  • Further reading