Chapter 52. Amyotrophic Lateral Sclerosis

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief3,4,
  2. Daniel D. Truong MD, FAAN Head5,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head6 and
  4. Roongroj Bhidayasiri MD, FRCP Director7,8
  1. Björn Oskarsson MD Assistant Professor1,
  2. Yvonne D. Rollins MD, PhD Assistant Professor of Neurology2 and
  3. Steven P. Ringel MD Professor of Neurology2

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch52

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Oskarsson, B., Rollins, Y. D. and Ringel, S. P. (2009) Amyotrophic Lateral Sclerosis, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch52

Editor Information

  1. 3

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 4

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 5

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 6

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 7

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 8

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. 1

    Clinical Neurology, University of California, Davis, Sacramento, CA, USA

  2. 2

    University of Colorado, Denver, Aurora, CO, USA

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • amyotrophic lateral sclerosis;
  • amyotrophic lateral sclerosis (ALS), fatal neurodegenerative disease affecting upper and lower motor neurons;
  • motor neuron disease (MND);
  • autosomal dominant familial ALS;
  • clinical and pathological overlap - between ALS and most common subgroup of frontotemporal dementia with MND-type inclusions;
  • disease with focal or asymmetric weakness in any region - along neuroaxis;
  • imaging the brain and spinal regions - clinically affected, being helpful;
  • non-invasive positive pressure ventilation (NIPPV) - in signs of nocturnal hypercapnia


This chapter contains sections titled:

  • Introduction

  • Epidemiology

  • Pathophysiology

  • Clinical features

  • Investigations

  • Treatment/management

  • Further reading