Chapter 54. Hereditary Spastic Paraplegia

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief2,3,
  2. Daniel D. Truong MD, FAAN Head4,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head5 and
  4. Roongroj Bhidayasiri MD, FRCP Director6,7
  1. Ildefonso Rodríguez-Leyva MD Professor of Neurology

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch54

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Rodríguez-Leyva, I. (2009) Hereditary Spastic Paraplegia, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch54

Editor Information

  1. 2

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 3

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 4

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 5

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 6

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 7

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosi, México

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • hereditary spastic paraplegia;
  • hereditary or familial spastic paraplegia, HSP, FSP group of inherited disorders;
  • onset of stiffness and weakness of hip and leg muscles - and associated gait disturbance tends to be insidious;
  • basic underlying defect(s) in HSP - remaining unknown;
  • Pes cavus in patient with HSP;
  • classification by mode of inheritance and genetic loci;
  • atrophy, confined to small muscles of feet and tibialis anterior muscles;
  • families suffering from HSP - in association with additional neurological features or “complicated HSP”


This chapter contains sections titled:

  • Introduction

  • Epidemiology

  • Pathophysiology

  • Clinical features

  • Investigations

  • Treatment/management

  • Further reading