Chapter 73. Leprosy

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief3,4,
  2. Daniel D. Truong MD, FAAN Head5,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head6 and
  4. Roongroj Bhidayasiri MD, FRCP Director7,8
  1. Minh Le MD Senior Lecturer of Neurology Consultant in Neurology Head Deputy Head1,2

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch73

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Le, M. (2009) Leprosy, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch73

Editor Information

  1. 3

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 4

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 5

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 6

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 7

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 8

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. 1

    Neurology Department, University Medical Center, Ho Chi Minh City, Vietnam

  2. 2

    Neurology Department, The University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • leprosy (Hansen's disease), result of chronic infection by Mycobacterium leprae;
  • Mycobacterium leprae, an acid-fast bacillus (AFB);
  • Tuberculoid Hansen's disease - characterized by intense cell-mediated immunity;
  • transmission through secretions - from nasal mucosa of untreated patients;
  • skin lesions, with associated sensory loss and enlarged peripheral nerves - cardinal symptoms and signs of leprosy;
  • TT patients having single or few macules or indurated skin lesions - hypopigmented, hypoesthetic, and anhydrotic;
  • indeterminate leprosy, hypopigmented, or slightly erythematous, poorly defined macules;
  • lepromatous leprosy – LL, characterized by infiltration of skin;
  • histopathological features of TT leprosy and LL leprosy


This chapter contains sections titled:

  • Introduction

  • Bacteriology and epidemiology

  • Pathogenesis and immunity

  • Clinical features

  • Leprosy reactions

  • Diagnosis

  • Other investigations

  • Differential diagnosis

  • Antileprotic treatment

  • Treatment of leprosy reactions

  • Further reading