Chapter 75. Lyme Disease

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief2,3,
  2. Daniel D. Truong MD, FAAN Head4,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head5 and
  4. Roongroj Bhidayasiri MD, FRCP Director6,7
  1. Patricia K. Coyle MD Professor Acting Chair

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch75

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Coyle, P. K. (2009) Lyme Disease, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch75

Editor Information

  1. 2

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 3

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 4

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 5

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 6

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 7

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. Department of Neurology, Stony Brook University Medical Center, Stony Brook, NY, USA

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • Lyme disease (borreliosis), clinical illness produced by infection with bacterial spirochete Borrelia burgdorferi;
  • Lyme disease, major tickborne infection in United States (US) and Europe;
  • Lyme disease, targeting skin, musculoskeletal, cardiac, and nervous systems;
  • EM, most common manifestation of Lyme disease - occurring in up to 90% of cases;
  • floridly inflammatory cerebrospinal fluid (CSF), headache and meningismus;
  • neurologic Lyme disease;
  • neurologic involvement - at all stages of Lyme disease;
  • brain single photon emission computed tomography (SPECT) - showing abnormal blood flow pattern;
  • tick co-pathogens - fairly dirty reservoirs, Ixodid ticks containing multiple B. burgdorferi strains, other spirochetes


This chapter contains sections titled:

  • Introduction

  • Epidemiology

  • Demographics

  • Tick vector

  • Organism

  • Clinical expression

  • Diagnosis

  • Therapy

  • Prevention

  • Tick co-pathogens

  • Pathogenesis

  • Chronic Lyme disease

  • Further reading