Chapter 76. Fungal Infections of the Central Nervous System

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief2,3,
  2. Daniel D. Truong MD, FAAN Head4,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head5 and
  4. Roongroj Bhidayasiri MD, FRCP Director6,7
  1. Thomas C. Cesario MD Professor Dean Emeritus

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch76

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Cesario, T. C. (2009) Fungal Infections of the Central Nervous System, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch76

Editor Information

  1. 2

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 3

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 4

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 5

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 6

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 7

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. University California, Irvine Orange, CA, USA

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • fungal infections of central nervous system;
  • Fungal infections of the central nervous system (CNS) - less common than bacterial infections;
  • Aspergillus species, ubiquitous in nature in soil, water, and organic materials;
  • Cerebrospinal fluid (CSF) findings - typically showing pleocytosis;
  • Cryptococcus and related fungi - encapsulated yeast detected in nature;
  • CNS infection with cryptococci - threat to immunocompromised patients;
  • non-AIDS-related cryptococcal meningitis - seen annually in United States;
  • coccidioidomycosis – Coccidioides immitis, a dimorphic fungus;
  • cryptococcal latex agglutination test (LACT) Don't take from here because I haven't checked it


This chapter contains sections titled:

  • Introduction

  • Candidiasis

  • Aspergillosis

  • Cryptococcosis

  • Coccidioidomycosis

  • Mucormycosis (zygomycosis)

  • Histoplasmosis

  • Blastomycosis

  • Further reading