Chapter 78. Amoebic Disease of the Central Nervous System

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief2,3,
  2. Daniel D. Truong MD, FAAN Head4,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head5 and
  4. Roongroj Bhidayasiri MD, FRCP Director6,7
  1. Melanie Walker MD Clinical Assistant Professor

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch78

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Walker, M. (2009) Amoebic Disease of the Central Nervous System, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch78

Editor Information

  1. 2

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 3

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 4

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 5

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 6

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 7

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. Departments of Neurology and Neurological Surgery, University of Washington School of Medicine, Seattle, WA, USA

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • amoebic disease of central nervous system;
  • Free-living amoebas Acanthamoeba species, Balamuthia mandrillaris, Entamoeba histolytica, and Naegleria fowleri;
  • granulomatous amoebic encephalitis (GAE);
  • PAM secondary to N. fowleri is an exceptionally uncommon result of CNS invasion of a healthy host;
  • Amoebic CNS disease presents a number of diagnostic challenges;
  • Imaging and pathologic findings in amoebic CNS disease;
  • Primary amoebic meningoencephalitis (PAM);
  • Rapid diagnosis is essential to the survival of patients with amoebic CNS disease


This chapter contains sections titled:

  • Introduction

  • Epidemiology

  • Pathophysiology

  • Clinical features

  • Investigations

  • Treatment/management

  • Further reading