Chapter 79. Toxoplasmosis of the Central Nervous System

  1. Robert P. Lisak MD, FAAN, FRCP Parker Webber Chair Professor Chair Neurologist-in-Chief Chief2,3,
  2. Daniel D. Truong MD, FAAN Head4,
  3. William M. Carroll MBBS, MD, FRACP, FRCP(E) Head5 and
  4. Roongroj Bhidayasiri MD, FRCP Director6,7
  1. Marylou V. Solbrig MD Professor

Published Online: 18 MAY 2010

DOI: 10.1002/9781444317008.ch79

International Neurology: A Clinical Approach

International Neurology: A Clinical Approach

How to Cite

Solbrig, M. V. (2009) Toxoplasmosis of the Central Nervous System, in International Neurology: A Clinical Approach (eds R. P. Lisak, D. D. Truong, W. M. Carroll and R. Bhidayasiri), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317008.ch79

Editor Information

  1. 2

    Wayne State University School of Medicine, Detroit, MI, USA

  2. 3

    Detroit Medical Center, Harper University Hospital, Detroit, MI, USA

  3. 4

    The Parkinson and Movement Disorder Institute, Memorial Neuroscience Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA

  4. 5

    Sir Charles Gairdner Hospital, Nedlands, Perth, Australia

  5. 6

    Chulalongkorn Comprehensive Movement Disorders Center, Chulalongkorn University Hospital, Bangkok, Thailand

  6. 7

    University of California at Los Angeles, School of Medicine, Los Angeles, CA, USA

Author Information

  1. Internal Medicine (Neurology) and Medical Microbiology, Health Sciences Center, University of Manitoba, Winnipeg, Manitoba, Canada

Publication History

  1. Published Online: 18 MAY 2010
  2. Published Print: 11 SEP 2009

ISBN Information

Print ISBN: 9781405157384

Online ISBN: 9781444317008



  • Toxoplasma gondii is an obligate intracellular protozoan infecting man, other mammals, and birds;
  • toxoplasmosis of the central nervous system;
  • Toxoplasma infections are common in man, and usually asymptomatic;
  • Central nervous system (CNS) toxoplasmosis occurs after acute generalized infection in children and adults;
  • Retinochoroiditis – Toxoplasmosis, most common cause of posterior uveitis in immunocompetent subjects;
  • Toxoplasma infection is almost always followed by chronic infection;
  • Toxoplasma encephalitis has been the most frequent cause of focal CNS infection in patients with AIDS;
  • combination of sulfadiazine and pyrimethamine is the classic and probably best means of treating active disease


This chapter contains sections titled:

  • Introduction

  • Epidemiology

  • Pathophysiology

  • Clinical features

  • Investigations

  • Treatment

  • Further reading