58. Disorders of Skin Colour

  1. Tony Burns MB, BS, FRCP Emeritus Consultant Dermatologist2,
  2. Stephen Breathnach MA, MB, BChir, MD, PhD, FRCP Consultant Dermatologist3,4,
  3. Neil Cox BSc, MB, ChB, FRCP(Lond & Edin) Consultant Dermatologist Visiting Professor5,6 and
  4. Christopher Griffiths BSc, MD, FRCP, FRCPath Professor of Dermatology Consultant Dermatologist7
  1. A. V. Anstey MD, FRCP Consultant Dermatologist

Published Online: 6 MAY 2010

DOI: 10.1002/9781444317633.ch58

Rook's Textbook of Dermatology, Eighth Edition

Rook's Textbook of Dermatology, Eighth Edition

How to Cite

Anstey, A. V. (2010) Disorders of Skin Colour, in Rook's Textbook of Dermatology, Eighth Edition (eds T. Burns, S. Breathnach, N. Cox and C. Griffiths), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444317633.ch58

Editor Information

  1. 2

    Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK

  2. 3

    St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK

  3. 4

    Epsom & St Helier University Hospitals NHS Trust, Epsom, Surrey, UK

  4. 5

    Department of Dermatology, Cumberland Infirmary, Carlisle CA2 7HY, UK

  5. 6

    University of Cumbria, Carlisle CA1 2HH, UK

  6. 7

    The Dermatology Centre, University of Manchester, Salford Royal Hospital, Salford, Manchester M6 8HD, UK

Author Information

  1. Department of Dermatology, Royal Gwent Hospital, Newport NP20 2UB, UK

Publication History

  1. Published Online: 6 MAY 2010
  2. Published Print: 22 MAR 2010

ISBN Information

Print ISBN: 9781405161695

Online ISBN: 9781444317633



  • skin colour disorders;
  • colour of skin;
  • melanocyte and epidermal melanin unit;
  • melanoblast migration and differentiation;
  • melanosome transfer to keratinocytes;
  • biochemistry of melanogenesis;
  • melanocyte regulation by endocrine factors - effects of oestrogens on cutaneous pigmentation;
  • other hereditary disorders with hypermelanosis;
  • Naegeli–Franceschetti–Jadassohn syndrome;
  • hypomelanotic macules of tuberous sclerosis


This chapter contains sections titled:

  • The colour of the skin [1-7]

  • The melanocyte [1-3]

  • Biochemistry of melanogenesis [1-5]

  • Regulation of human pigmentation by ultraviolet light and by endocrine, paracrine and autocrine factors

  • Biological significance of melanin

  • Classification of disorders of melanin pigmentation

  • Constitutive pigmentation, human pigmentation and the response to sun exposure

  • Hypermelanosis

  • Hypomelanosis

  • Endogenous non-melanin pigmentation [1]

  • Exogenous pigments

  • References