Chapter 5. Photodynamic Photorejuvenation

  1. David J. Goldberg MD, JD5,6,7
  1. Michael H. Gold MD Clinical Assistant Professor Visiting Professor of Dermatology1,2,3,4

Published Online: 11 MAY 2010

DOI: 10.1002/9781444318395.ch5

Facial Resurfacing

Facial Resurfacing

How to Cite

Gold, M. H. (2010) Photodynamic Photorejuvenation, in Facial Resurfacing (ed D. J. Goldberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444318395.ch5

Editor Information

  1. 5

    Skin Laser and Surgery Specialists of New York & New Jersey, New York, NY, USA

  2. 6

    Mount Sinai School of Medicine, New York, NY, USA

  3. 7

    Sanctuary Medical Aesthetic Center, Boca Raton, FL, USA

Author Information

  1. 1

    Gold Skin Care Center, Tennessee Clinical Research Center, Nashville, Tennessee, USA

  2. 2

    Vanderbilt University School of Medicine, Department of Dermatology, Vanderbilt University School of Medicine, School of Nursing, Nashville, Tennessee, USA

  3. 3

    Huashan Hospital, Fudan University, Shanghai, China

  4. 4

    Number One Hospital, China Medical University, Shenyang, China

Publication History

  1. Published Online: 11 MAY 2010
  2. Published Print: 5 FEB 2010

ISBN Information

Print ISBN: 9781405190800

Online ISBN: 9781444318395



  • photodynamic photorejuvenation in actinic keratose treatment;
  • photodynamic therapy (PDT) - in dermatology offices for cutaneous disorders;
  • American pathway, ALA injection into cells - converted to protoporphyrin IX (PpIX);
  • PDT, distinct development pathways - American path and the European path;
  • photorejuvenation - photodynamic photorejuvenation and photorejuvenation concept;
  • American path for PDT - domination over the years by ALA;
  • open-label ALA-PDT clinical trials - AKs and photorejuvenation;
  • split-face clinical trials in USA - AKs and photorejuvenation;
  • ALA-IPL split face protocol - three split-face ALA-IPL treatments at 3-week intervals;
  • ALA-PDT and MAL-PDT, treatment of AKs and signs of photodamage


This chapter contains sections titled:

  • Introduction

  • Historical background

  • Recent developments

  • Photorejuvenation: from the beginning

  • Pivotal US trials for ALA-PDT: AKs

  • Open-label ALA-PDT clinical trials: AKs and photorejuvenation

  • Split-face clinical trials in the USA: AKs and photorejuvenation

  • Metvix/Metvixia: the methyl ester of ALA for AKs, non-melanoma skin cancers, and photorejuvenation

  • Conclusion

  • References