Chapter 3. The Design of Animal Experiments

  1. Robert Hubrecht and
  2. James Kirkwood
  1. Michael F. W. Festing

Published Online: 8 FEB 2010

DOI: 10.1002/9781444318777.ch3

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals, Eighth Edition

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals, Eighth Edition

How to Cite

Festing, M. F. W. (2010) The Design of Animal Experiments, in The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals, Eighth Edition (eds R. Hubrecht and J. Kirkwood), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444318777.ch3

Editor Information

  1. UFAW, The Old School, Brewhouse Hill, Wheathampstead, Hertfordshire AL4 8AN, UK

Author Information

  1. c/o Understanding Animal Research, 25 Shaftsbury Avenue, London W1D 7EG, UK

Publication History

  1. Published Online: 8 FEB 2010
  2. Published Print: 26 MAR 2010

ISBN Information

Print ISBN: 9781405175234

Online ISBN: 9781444318777

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Keywords:

  • design of animal experiments;
  • research workers, animal house staff and ethical review committee members;
  • research strategy and models in research;
  • pilot experiments - exploratory experiments and confirmatory experiments;
  • optimum group size - size of differences, group means and inter-individual variability;
  • dependent and independent variables - variables in experiments;
  • randomised controlled, double-blinded clinical trial - gold standard for design;
  • measurement error and variability in procedures;
  • analysis of variance and t-test - comparing means of two;
  • factorial experimental designs

Summary

This chapter contains sections titled:

  • Introduction

  • Research strategy and the use of models in research

  • Steps in the design of an experiment

  • Statistical analysis of planned experiments

  • Some experimental designs

  • Concluding remarks

  • References