Chapter 4. Introduction to Laboratory Animal Genetics

  1. Robert Hubrecht,
  2. James Kirkwood
  1. Michael F. W. Festing1,
  2. Cathleen Lutz Associate Director2

Published Online: 8 FEB 2010

DOI: 10.1002/9781444318777.ch4

Book Title

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals, Eighth Edition

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals, Eighth Edition

Additional Information

How to Cite

Festing, M. F. W. and Lutz, C. (2010) Introduction to Laboratory Animal Genetics, in The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals, Eighth Edition (eds R. Hubrecht and J. Kirkwood), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444318777.ch4

Editor Information

  1. UFAW, The Old School, Brewhouse Hill, Wheathampstead, Hertfordshire AL4 8AN, UK

Author Information

  1. 1

    c/o Understanding Animal Research, 25 Shaftsbury Avenue, London W1D 7EG, UK

  2. 2

    Genetic Resource Sciences; Mouse Repository, The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA

Publication History

  1. Published Online: 8 FEB 2010
  2. Published Print: 26 MAR 2010

ISBN Information

Print ISBN: 9781405175234

Online ISBN: 9781444318777

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CHAPTER TOOLS

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Keywords:

  • laboratory animal genetics - research workers wishing to use animals;
  • different species, stocks, inbred strains, mutants and transgenic strains - suitable as experimental animals;
  • mutations and polymorphisms;
  • mice and rats - International Committee on Standardised Genetic Nomenclature of Mouse and The Rat Genome and Nomenclature Committee;
  • ‘tabby’ gene in mouse - sex-linked mode of inheritance;
  • genes in populations of animals and Hardy–Weinberg equilibrium;
  • genetic background - rest of genome apart from specified gene or genes;
  • polygenic characters and quantitative trait loci;
  • inbred strain nomenclature;
  • chemical mutagenesis - using ENU, good yield of mutants

Summary

This chapter contains sections titled:

  • Introduction

  • Strains and stocks of laboratory animals

  • Genetic quality control

  • Genetically modified (transgenic and mutant) strains

  • Concluding remarks

  • Useful websites and collaborative genetics projects

  • Glossary

  • References

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