Chapter 17. Animal Models

  1. Peter G. Miller2,
  2. John Strang3,4 and
  3. Peter M. Miller5
  1. Leigh V. Panlilio,
  2. Charles W. Schindler and
  3. Steven R. Goldberg

Published Online: 16 FEB 2010

DOI: 10.1002/9781444318852.ch17

Addiction Research Methods

Addiction Research Methods

How to Cite

Panlilio, L. V., Schindler, C. W. and Goldberg, S. R. (2010) Animal Models, in Addiction Research Methods (eds P. G. Miller, J. Strang and P. M. Miller), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444318852.ch17

Editor Information

  1. 2

    School of Psychology, Deakin University, Victoria, Australia

  2. 3

    National Addiction Centre Institute of Psychiatry, Kings College London, UK

  3. 4

    South London and Maudsley NHS Foundation Trust, London, UK

  4. 5

    Center for Drug and Alcohol Programs, Medical University & South Carolina, Charleston, SC, USA

Author Information

  1. Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, MD, USA

Publication History

  1. Published Online: 16 FEB 2010
  2. Published Print: 2 APR 2010

ISBN Information

Print ISBN: 9781405176637

Online ISBN: 9781444318852



  • animal models;
  • specific animal models - aspects of substance use and addiction;
  • addictive drugs, functioning as rewards - positive reinforcement;
  • basic principles of behavior - effects of environmental cues;
  • drug self-administration - simple schedules;
  • drug self-administration - dose–effect curves to assess effects of treatments;
  • drug self-administration - measuring reinforcing effects of drugs;
  • drug self-administration - modelling effects of environmental cues with second-order schedules;
  • relapse, important obstacles in treating addiction


This chapter contains sections titled:

  • Introduction

  • Basic principles of behaviour: Reinforcement

  • Basic principles of behaviour: Effects of environmental cues

  • Drug self-administration: Simple schedules

  • Drug self-administration: Using dose–effect curves to assess the effects of treatments

  • Drug self-administration: Measuring the reinforcing effects of drugs

  • Drug self-administration: Modelling the effects of environmental cues with second-order schedules

  • Drug self-administration: Reinstatement

  • Drug self-administration: Modelling the uncontrolled and compulsive nature of addiction

  • Intracranial drug self-administration and intracranial electrical self-stimulation

  • Drug self-administration: Advantages and disadvantages

  • Conditioned place preference

  • Drug discrimination

  • Locomotor activity

  • Adjunct procedures

  • Integration of behavioural and neuroscience techniques

  • References for figures

  • References and recommended readings