You have free access to this content

Chapter 4. Experimental Design Issues in Addiction Research

  1. Peter G. Miller2,
  2. John Strang3,4 and
  3. Peter M. Miller5
  1. Robert West

Published Online: 16 FEB 2010

DOI: 10.1002/9781444318852.ch4

Addiction Research Methods

Addiction Research Methods

How to Cite

West, R. (2010) Experimental Design Issues in Addiction Research, in Addiction Research Methods (eds P. G. Miller, J. Strang and P. M. Miller), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444318852.ch4

Editor Information

  1. 2

    School of Psychology, Deakin University, Victoria, Australia

  2. 3

    National Addiction Centre Institute of Psychiatry, Kings College London, UK

  3. 4

    South London and Maudsley NHS Foundation Trust, London, UK

  4. 5

    Center for Drug and Alcohol Programs, Medical University & South Carolina, Charleston, SC, USA

Author Information

  1. Department of Epidemiology and Public Health, University College London, London, UK

Publication History

  1. Published Online: 16 FEB 2010
  2. Published Print: 2 APR 2010

ISBN Information

Print ISBN: 9781405176637

Online ISBN: 9781444318852

SEARCH

References

  • Altman, D. G., Whitehead, J., Parmar, M. K., Stenning, S. P., Fayers, P. M. & Machin, D. (1995) Randomised consent designs in cancer clinical trials. European Journal of Cancer, 31A(12), 19341944.
  • Anthonisen, N. R., Skeans, M. A., Wise, R. A., Manfreda, J., Kanner, R. E. & Connett, J. E. (2005) The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Annals of Internal Medicine, 142(4), 233239.
  • Bland, J. M. & Altman, D. G. (1995) Multiple significance tests: the Bonferroni method. BMJ, 310(6973), 170.
  • Brown, C. A. & Lilford, R. J. (2006) The stepped wedge trial design: a systematic review. BMC Medical Research Methodology, 6, 54.
  • Carroll, K. M. & Rounsaville, B. J. (2007) A vision of the next generation of behavioral therapies research in the addictions. Addiction, 102(6), 850862; discussion 863–859.
  • Collins, L. M., Murphy, S. A., Nair, V. N. & Strecher, V. J. (2005) A strategy for optimizing and evaluating behavioral interventions. Annals of Behavioral Medicine, 30(1), 6573.
  • Craig, P., Dieppe, P., Macintyre, S., Michie, S., Nazareth, I. & Petticrew, M. (2008) Developing and evaluating complex interventions: the new Medical Research Council guidance. BMJ, 337, a1655.
  • Crano, W. D. & Prislin, R. (2006) Attitudes and persuasion. Annual Review of Psychology, 57, 345374.
  • DuVal, G. (2004) Ethics in psychiatric research: study design issues. Canadian Journal of Psychiatry, 49(1), 5559.
  • Heatherton, T. F., Kozlowski, L. T., Frecker, R. C. & Fagerstrom, K. O. (1991) The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire. British Journal of Addiction, 86(9), 11191127.
  • Hughes, J. R., Keely, J. P., Niaura, R. S., Ossip-Klein, D. J., Richmond, R. L. & Swan, G. E. (2003) Measures of abstinence in clinical trials: issues and recommendations. Nicotine and Tobacco Research, 5(1), 1325.
  • Humphreys, K., Weingardt, K. R., Horst, D., Joshi, A. A. & Finney, J. W. (2005) Prevalence and predictors of research participant eligibility criteria in alcohol treatment outcome studies, 1970–98. Addiction, 100(9), 12491257.
  • Janevic, M. R., Janz, N. K., Dodge, J. A., Lin, X., Pan, W., Sinco, B. R. & Clark, N. M. (2003) The role of choice in health education intervention trials: a review and case study. Social Science and Medicine, 56(7), 15811594.
  • Kaner, E., Lock, C., Heather, N., McNamee, P. & Bond, S. (2003) Promoting brief alcohol intervention by nurses in primary care: a cluster randomised controlled trial. Patient Education and Counseling, 51(3), 277284.
  • Mahon, J., Laupacis, A., Donner, A. & Wood, T. (1996) Randomised study of n of 1 trials versus standard practice. BMJ, 312(7038), 10691074.
  • McKee, S. A., O'Malley, S. S., Shi, J., Mase, T. & Krishnan-Sarin, S. (2008) Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration. Psychopharmacology (Berl), 196(2), 189200.
  • Nair, V., Strecher, V., Fagerlin, A., Ubel, P., Resnicow, K., Murphy, S., Little, R., Chakraborty, B. & Zhang, A. (2008) Screening experiments and the use of fractional factorial designs in behavioral intervention research. American Journal of Public Health, 98(8), 13541359.
  • Nides, M., Glover, E. D., Reus, V. I., Christen, A. G., Make, B. J., Billing, C. B., Jr & Williams, K. E. (2008) Varenicline versus bupropion SR or placebo for smoking cessation: a pooled analysis. American Journal of Health Behavior, 32(6), 664675.
  • Strecher, V. J., McClure, J., Alexander, G., Chakraborty, B., Nair, V., Konkel, J., Greene, S., Couper, M., Carlier, C., Wiese, C., Little, R., Pomerleau, C. & Pomerleau, O. (2008a) The role of engagement in a tailored web-based smoking cessation program: randomized controlled trial. Journal of Medical Internet Research, 10(5), e36.
  • Strecher, V. J., McClure, J. B., Alexander, G. L., Chakraborty, B., Nair, V. N., Konkel, J., Greene, S., Couper, M., Carlier, C., Wiese, C., Little, R., Pomerleau, C. & Pomerleau, O. (2008b) Web-based smoking-cessation programs: results of a randomized trial. American Journal of Preventive Medicine, 34(5), 373381.
  • Tiffany, S. T. & Drobes, D. J. (1991) The development and initial validation of a questionnaire on smoking urges. British Journal of Addiction, 86(11), 14671476.
  • Ussher, M. H., Taylor, A. & Faulkner, G. (2008) Exercise interventions for smoking cessation. Cochrane Database Systematic Reviews, 4, CD002295.
  • Velicer, W. (1994) Time series models of individual substance abusers. In: L. M.Collins & L.Seitz (eds) Advances in Data Analysis for Prevention Intervention Research: NIDA Research Monograph 142. Rockville, MD: USDHHS, pp. 264302.
  • West, R. (2006) Defining and assessing nicotine dependence in humans. In: G.Bock & J.Goode (eds) Understanding Nicotine and Tobacco Addiction. London: Wiley, pp. 3651.
  • West, R. (2007) The clinical significance of ‘small' effects of smoking cessation treatments. Addiction, 102(4), 506509.
  • West, R. (2009) The multiple facets of cigarette addiction and what they mean for encouraging and helping smokers to stop. COPD (in press).
  • West, R., Baker, C. L., Cappelleri, J. C. & Bushmakin, A. G. (2008) Effect of varenicline and bupropion SR on craving, nicotine withdrawal symptoms, and rewarding effects of smoking during a quit attempt. Psychopharmacology (Berl), 197(3), 371377.
  • West, R., Hajek, P., Stead, L. & Stapleton, J. (2005) Outcome criteria in smoking cessation trials: proposal for a common standard. Addiction, 100(3), 299303.
  • West, R., Ussher, M., Evans, M. & Rashid, M. (2006) Assessing DSM-IV nicotine withdrawal symptoms: a comparison and evaluation of five different scales. Psychopharmacology (Berl), 184(3–4), 619627.
  • Recommended readings
  • Craig, P., Dieppe, P., Macintyre, S., Michie, S., Nazareth, I. & Petticrew, M. (2008) Developing and evaluating complex interventions: the new Medical Research Council guidance. BMJ, 337, a1655.
  • DuVal, G. (2004) Ethics in psychiatric research: study design issues. Canadian Journal of Psychiatry, 49(1), 5559.