Chapter 28. HBeAg-Negative Chronic Hepatitis B Infection with Abnormal Transaminases and Minimal Changes on Liver Biopsy

  1. Graham R. Foster FRCP, PhD Professor1 and
  2. K. Rajender Reddy MD, FACP, FACG, FRCP Professor Director2
  1. Graham R. Foster FRCP, PhD Professor

Published Online: 10 MAR 2010

DOI: 10.1002/9781444319590.ch28

Clinical Dilemmas in Viral Liver Disease

Clinical Dilemmas in Viral Liver Disease

How to Cite

Foster, G. R. (2010) HBeAg-Negative Chronic Hepatitis B Infection with Abnormal Transaminases and Minimal Changes on Liver Biopsy, in Clinical Dilemmas in Viral Liver Disease (eds G. R. Foster and K. R. Reddy), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444319590.ch28

Editor Information

  1. 1

    Queen Mary's University of London, Blizard Institute of Cell and Molecular Science, The Liver Unit, London, UK

  2. 2

    University of Pennsylvania, Philadelphia, PA, USA

Author Information

  1. Queen Mary's University of London, Blizard Institute of Cell and Molecular Science, The Liver Unit, London, UK

Publication History

  1. Published Online: 10 MAR 2010
  2. Published Print: 31 MAR 2010

ISBN Information

Print ISBN: 9781405179058

Online ISBN: 9781444319590

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Keywords:

  • HBV;
  • minimal disease;
  • treatment;
  • liver biopsy

Summary

The optimal management of patients with HBeAg-negative chronic hepatitis B who have minimal histological disease is unclear. The long-term natural history of these patients with presumed early disease is unclear and the benefits of therapy are uncertain. Management of such patients should involve a careful discussion of the risks and benefits of therapy with the patient and a final decision regarding therapy should take into account the views of the patient.