Chapter 4. ‘Albinism’ and the Failure of Normal Melanosome Maturation

  1. M. Lynn Lamoreux1,
  2. Véronique Delmas2,
  3. Lionel Larue2 and
  4. Dorothy C. Bennett3

Published Online: 6 MAY 2010

DOI: 10.1002/9781444319651.ch4

The Colors of Mice: A Model Genetic Network

The Colors of Mice: A Model Genetic Network

How to Cite

Lamoreux, M. L., Delmas, V., Larue, L. and Bennett, D. C. (2010) ‘Albinism’ and the Failure of Normal Melanosome Maturation, in The Colors of Mice: A Model Genetic Network, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444319651.ch4

Author Information

  1. 1

    Bryan, Texas, USA

  2. 2

    Developmental Genetics of Melanocytes, Institut Curie, Orsay, France

  3. 3

    Molecular and Metabolic Signalling Centre, St. George's, University of London, UK

Publication History

  1. Published Online: 6 MAY 2010
  2. Published Print: 16 APR 2010

ISBN Information

Print ISBN: 9781405179546

Online ISBN: 9781444319651

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Keywords:

  • ‘albinism’ and failure - normal melanosome maturation;
  • geneticists' outlook - generating processes of normally pigmented melanosome;
  • melanosomal matrix - Si encoded structural protein;
  • enzymes catalyzing melanogenesis - tyrosinase-related proteins involved in eumelanogenesis;
  • membrane proteins regulating internal milieu of melanosome;
  • melanosome transport - geranylgeranyl transferase adding hydrophobic phenyl groups

Summary

This chapter contains sections titled:

  • Background

  • The melanosomal matrix

  • The enzymes that catalyze melanogenesis

  • Membrane proteins that regulate the internal milieu of the melanosome

  • Protein processing and routing to the maturing melanosome

  • Melanosome transport