Chapter 14. Diffuse Slowing—Metabolic Encephalopathy—Hypoglycemia[1–3]

  1. Peter W. Kaplan MB, FRCP1 and
  2. Thien Nguyen MD, PhD2

Published Online: 4 SEP 2010

DOI: 10.1002/9781444322972.ch14

Clinical Electrophysiology

Clinical Electrophysiology

How to Cite

Kaplan, P. W. and Nguyen, T. (2010) Diffuse Slowing—Metabolic Encephalopathy—Hypoglycemia[1–3], in Clinical Electrophysiology, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444322972.ch14

Author Information

  1. 1

    Department of Neurology, The Johns Hopkins University School of Medicine & Johns Hopkins Bayview Medical Center, Baltimore, MA, USA

  2. 2

    Department of Neurology, The Johns Hopkins University School of Medicine & The Johns Hopkins Hospital, Baltimore, MA, USA

Publication History

  1. Published Online: 4 SEP 2010
  2. Published Print: 8 OCT 2010

ISBN Information

Print ISBN: 9781405185295

Online ISBN: 9781444322972



  • Diffuse slowing—metabolic encephalopathy—hypoglycemia;
  • Clinical Correlates - the patient can follow commands, localize to pain, and even in coma the brainstem reflexes are usually present;
  • Clinical Evaluation - Examine for evidence of insulin injections;
  • Prognosis - severe low glucose can result in mild to moderate permanent diffuse cerebral deficit, vegetative states, or death;
  • Glucose infusion and supportive ICU care


This chapter contains sections titled:

  • Clinical Correlates

  • Etiology

  • Clinical Evaluation

  • Ancillary Testing

  • Differential Diagnosis

  • Prognosis

  • Treatment

  • References