Chapter 47. Approach to the use of Glucocorticoids in Pregnancy for Nonobstetric Indications

  1. Raymond O. Powrie MD, FRCP, FACP Professor of Medicine and Obstetrics and Gynecology Senior Vice President1,
  2. Michael F. Greene MD Professor of Obstetrics Chief of Obstetrics2,3 and
  3. William Camann MD Associate Professor of Anaesthesia Director of Obstetric Anesthesiology4
  1. Kenneth K. Chen and
  2. Raymond O. Powrie MD, FRCP, FACP Professor of Medicine and Obstetrics and Gynecology Senior Vice President

Published Online: 9 JUL 2010

DOI: 10.1002/9781444323016.ch47

de Swiet's Medical Disorders in Obstetric Practice, Fifth Edition

de Swiet's Medical Disorders in Obstetric Practice, Fifth Edition

How to Cite

Chen, K. K. and Powrie, R. O. (2010) Approach to the use of Glucocorticoids in Pregnancy for Nonobstetric Indications, in de Swiet's Medical Disorders in Obstetric Practice, Fifth Edition (eds R. O. Powrie, M. F. Greene and W. Camann), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444323016.ch47

Editor Information

  1. 1

    Warren Alpert Medical School of Brown University, Quality and Clinical Effectiveness Women & Infants' Hospital of Rhode Island Providence, RI, USA

  2. 2

    Gynecology and Reproductive Biology, Harvard Medical School, USA

  3. 3

    Massachusetts General Hospital, Boston, MA, USA

  4. 4

    Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Author Information

  1. Warren Alpert Medical School of Brown University, Quality and Clinical Effectiveness Women & Infants' Hospital of Rhode Island Providence, RI, USA

Publication History

  1. Published Online: 9 JUL 2010
  2. Published Print: 18 JUN 2010

ISBN Information

Print ISBN: 9781405148474

Online ISBN: 9781444323016

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Keywords:

  • approach to use of glucocorticoids - in pregnancy for nonobstetric indications;
  • glucocorticoids, essential for life - wide spectrum of effects on organ systems;
  • glucocorticoid safety in pregnancy;
  • side effects of exogenous glucocorticoid use;
  • stress-dose glucocorticoids - at time of labor and delivery;
  • glucocorticoids, and insulin resistance - unmasking impaired glucose tolerance in women at risk;
  • WHO - warrants stress-dose steroids;
  • testing HPA axis by Cosyntropin (tetracosactide) test;
  • HPA axis test - administering synthetic analog of adrenocorticotropin hormone (ACTH);
  • major surgical stress - glucocorticoid target, 100–150 mg of hydrocortisone

Summary

This chapter contains sections titled:

  • Introduction

  • Safety of glucocorticoids in pregnancy

  • Use of stress-dose glucocorticoids at time of labor and delivery

  • References