Chapter 10. Abnormalities of Insulin Secretion and β-Cell Defects in Type 2 Diabetes

  1. Richard I. G. Holt MA, MB BChir, PhD, FRCP, FHEA Professor in Diabetes & Endocrinology2,
  2. Clive S. Cockram MB BS, BSc, MD (Lond), FRCP, FRACP, FHKAM (Med) Emeritus Professor of Medicine3,
  3. Allan Flyvbjerg MD, DMSc Professor of Clinical Endocrinology Chair4 and
  4. Barry J. Goldstein MD, PhD, FACP, FACE Therapeutic Area Head Vice President5
  1. Mazen Alsahli MD Professor of Medicine and
  2. John E. Gerich MD Professor of Medicine

Published Online: 9 JUL 2010

DOI: 10.1002/9781444324808.ch10

Textbook of Diabetes, Fourth Edition

Textbook of Diabetes, Fourth Edition

How to Cite

Alsahli, M. and Gerich, J. E. (2010) Abnormalities of Insulin Secretion and β-Cell Defects in Type 2 Diabetes, in Textbook of Diabetes, Fourth Edition (eds R. I. G. Holt, C. S. Cockram, A. Flyvbjerg and B. J. Goldstein), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444324808.ch10

Editor Information

  1. 2

    Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton, UK

  2. 3

    Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China

  3. 4

    Department of Endocrinology and Internal Medicine, The Medical Research Laboratories, Aarhus University Hospital – Aarhus University, Aarhus, Denmark

  4. 5

    Clinical Research, Metabolism Merck Research Laboratories Rahway, NJ, USA

Author Information

  1. University of Rochester School of Medicine, Rochester, NY, USA

Publication History

  1. Published Online: 9 JUL 2010
  2. Published Print: 9 JUL 2010

ISBN Information

Print ISBN: 9781405191814

Online ISBN: 9781444324808

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Keywords:

  • maturity - onset diabetes of youth (MODY);
  • Impaired β-cell function vs insulin resistance;
  • free fatty acid (FFA);
  • Role of β - cell defects in the natural history of type 2 diabetes;
  • transcription factor 7 - like 2 gene (TCF7L2);
  • Islet and islet cell changes in type 2 diabetes;
  • glucose-dependent insulinotropic peptide [GIP];
  • oral glucose tolerance tests (OGTT)

Summary

This chapter contains sections titled:

  • Impaired β-cell function vs insulin resistance

  • Role of β-cell defects in the natural history of type 2 diabetes

  • Insulin secretion in type 2 diabetes, in IGT and in genetically predisposed individuals with normal glucose tolerance

  • Possible mechanisms

  • Islet and islet cell changes in type 2 diabetes

  • Conclusions

  • References