Chapter 11. Insulin Resistance in Type 2 Diabetes

  1. Richard I. G. Holt MA, MB BChir, PhD, FRCP, FHEA Professor in Diabetes & Endocrinology2,
  2. Clive S. Cockram MB BS, BSc, MD (Lond), FRCP, FRACP, FHKAM (Med) Emeritus Professor of Medicine3,
  3. Allan Flyvbjerg MD, DMSc Professor of Clinical Endocrinology Chair4 and
  4. Barry J. Goldstein MD, PhD, FACP, FACE Therapeutic Area Head Vice President5
  1. Hannele Yki-Järvinen MD, FRCP Professor of Medicine

Published Online: 9 JUL 2010

DOI: 10.1002/9781444324808.ch11

Textbook of Diabetes, Fourth Edition

Textbook of Diabetes, Fourth Edition

How to Cite

Yki-Järvinen, H. (2010) Insulin Resistance in Type 2 Diabetes, in Textbook of Diabetes, Fourth Edition (eds R. I. G. Holt, C. S. Cockram, A. Flyvbjerg and B. J. Goldstein), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444324808.ch11

Editor Information

  1. 2

    Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton, UK

  2. 3

    Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China

  3. 4

    Department of Endocrinology and Internal Medicine, The Medical Research Laboratories, Aarhus University Hospital – Aarhus University, Aarhus, Denmark

  4. 5

    Clinical Research, Metabolism Merck Research Laboratories Rahway, NJ, USA

Author Information

  1. Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland

Publication History

  1. Published Online: 9 JUL 2010
  2. Published Print: 9 JUL 2010

ISBN Information

Print ISBN: 9781405191814

Online ISBN: 9781444324808

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Keywords:

  • Insulin resistance - definitions and role in the natural history of type 2 diabetes;
  • very low density lipoprotein (VLDL);
  • non - esterified fatty acid (NEFA);
  • Metabolic syndrome and non - alcoholic fatty liver disease;
  • International Diabetes Federation (IDF);
  • non - alcoholic fatty liver disease (NAFLD);
  • Insulin resistance in the liver;
  • Insulin resistance in adipose tissue;
  • Insulin resistance in skeletal muscle;
  • Resistance to other actions of insulin

Summary

This chapter contains sections titled:

  • Insulin resistance – definitions and role in the natural history of type 2 diabetes

  • Metabolic syndrome and non - alcoholic fatty liver disease

  • Insulin resistance in the liver

  • Insulin resistance in adipose tissue

  • Insulin resistance in skeletal muscle

  • Resistance to other actions of insulin

  • Conclusions

  • References