Chapter 12. The Genetics of Type 2 Diabetes: From Candidate Gene Biology to Genome-Wide Studies

  1. Richard I. G. Holt MA, MB BChir, PhD, FRCP, FHEA Professor in Diabetes & Endocrinology3,
  2. Clive S. Cockram MB BS, BSc, MD (Lond), FRCP, FRACP, FHKAM (Med) Emeritus Professor of Medicine4,
  3. Allan Flyvbjerg MD, DMSc Professor of Clinical Endocrinology Chair5 and
  4. Barry J. Goldstein MD, PhD, FACP, FACE Therapeutic Area Head Vice President6
  1. Martine Vaxillaire PharmD, PhD Research Director1 and
  2. Philippe Froguel MD, PhD1,2

Published Online: 9 JUL 2010

DOI: 10.1002/9781444324808.ch12

Textbook of Diabetes, Fourth Edition

Textbook of Diabetes, Fourth Edition

How to Cite

Vaxillaire, M. and Froguel, P. (2010) The Genetics of Type 2 Diabetes: From Candidate Gene Biology to Genome-Wide Studies, in Textbook of Diabetes, Fourth Edition (eds R. I. G. Holt, C. S. Cockram, A. Flyvbjerg and B. J. Goldstein), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444324808.ch12

Editor Information

  1. 3

    Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton, UK

  2. 4

    Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China

  3. 5

    Department of Endocrinology and Internal Medicine, The Medical Research Laboratories, Aarhus University Hospital – Aarhus University, Aarhus, Denmark

  4. 6

    Clinical Research, Metabolism Merck Research Laboratories Rahway, NJ, USA

Author Information

  1. 1

    CNRS 8090 and Pasteur Institute, Lille, France

  2. 2

    Section of Genomic Medicine, Imperial College London, London, UK

Publication History

  1. Published Online: 9 JUL 2010
  2. Published Print: 9 JUL 2010

ISBN Information

Print ISBN: 9781405191814

Online ISBN: 9781444324808

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Keywords:

  • Genetic architecture of type 2 diabetes: a complex interaction of genetic susceptibility and environmental exposures;
  • Type 2 diabetes mellitus (T2DM);
  • genome - wide association (GWA);
  • Genes involved in monogenic diabetes and their relevance to adult - onset T2DM;
  • Search for T2DM genes in the pre - GWA era;
  • glycogen synthase gene (GYS1);
  • genome - wide familial linkage (GWL);
  • The era of GWA studies improved knowledge of T2DM susceptibility genes

Summary

This chapter contains sections titled:

  • Genetic architecture of type 2 diabetes: a complex interaction of genetic susceptibility and environmental exposures

  • Genes involved in monogenic diabetes and their relevance to adult - onset T2DM

  • Search for T2DM genes in the pre - GWA era

  • The era of GWA studies improved knowledge of T2DM susceptibility genes

  • Pharmacogenetics of T2DM in adults

  • Conclusions and perspectives

  • References