Chapter 38. Diabetic Peripheral Neuropathy

  1. Richard I. G. Holt MA, MB BChir, PhD, FRCP, FHEA Professor in Diabetes & Endocrinology3,
  2. Clive S. Cockram MB BS, BSc, MD (Lond), FRCP, FRACP, FHKAM (Med) Emeritus Professor of Medicine4,
  3. Allan Flyvbjerg MD, DMSc Professor of Clinical Endocrinology Chair5 and
  4. Barry J. Goldstein MD, PhD, FACP, FACE Therapeutic Area Head Vice President6
  1. Dan Ziegler MD, FRCPE Professor1,2

Published Online: 9 JUL 2010

DOI: 10.1002/9781444324808.ch38

Textbook of Diabetes, Fourth Edition

Textbook of Diabetes, Fourth Edition

How to Cite

Ziegler, D. (2010) Diabetic Peripheral Neuropathy, in Textbook of Diabetes, Fourth Edition (eds R. I. G. Holt, C. S. Cockram, A. Flyvbjerg and B. J. Goldstein), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444324808.ch38

Editor Information

  1. 3

    Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton, UK

  2. 4

    Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China

  3. 5

    Department of Endocrinology and Internal Medicine, The Medical Research Laboratories, Aarhus University Hospital – Aarhus University, Aarhus, Denmark

  4. 6

    Clinical Research, Metabolism Merck Research Laboratories Rahway, NJ, USA

Author Information

  1. 1

    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Düsseldorf, Germany

  2. 2

    Department of Metabolic Diseases, University Hospital, Düsseldorf, Germany

Publication History

  1. Published Online: 9 JUL 2010
  2. Published Print: 9 JUL 2010

ISBN Information

Print ISBN: 9781405191814

Online ISBN: 9781444324808



  • Classification and epidemiology;
  • Focal and multifocal neuropathies;
  • Central nervous system dysfunction;
  • Quantitative sensory testing;
  • Role of intensive diabetes therapy in treatment and prevention of diabetic neuropathy;
  • Treatment based on pathogenetic concepts;
  • Pharmacologic treatment of painful neuropathy;
  • Non - pharmacologic treatment of painful neuropathy;
  • Selective serotonin reuptake inhibitors (SSRI);
  • Serotonin noradrenaline reuptake inhibitors (SNRI)


This chapter contains sections titled:

  • Classification and epidemiology

  • Clinical manifestations

  • Pathogenetic mechanisms

  • Diagnostic assessment

  • Treatment

  • References