Chapter 39. The Pathogenesis of Macrovascular Complications Including Atherosclerosis in Diabetes

  1. Richard I. G. Holt MA, MB BChir, PhD, FRCP, FHEA Professor in Diabetes & Endocrinology5,
  2. Clive S. Cockram MB BS, BSc, MD (Lond), FRCP, FRACP, FHKAM (Med) Emeritus Professor of Medicine6,
  3. Allan Flyvbjerg MD, DMSc Professor of Clinical Endocrinology Chair7 and
  4. Barry J. Goldstein MD, PhD, FACP, FACE Therapeutic Area Head Vice President8
  1. Riccardo Candido MD, PhD1,
  2. Mark E. Cooper MD, PhD Director Head2 and
  3. Karin A. M. Jandeleit-Dahm MD, PhD, FRACP Professor3,4

Published Online: 9 JUL 2010

DOI: 10.1002/9781444324808.ch39

Textbook of Diabetes, Fourth Edition

Textbook of Diabetes, Fourth Edition

How to Cite

Candido, R., Cooper, M. E. and Jandeleit-Dahm, K. A. M. (2010) The Pathogenesis of Macrovascular Complications Including Atherosclerosis in Diabetes, in Textbook of Diabetes, Fourth Edition (eds R. I. G. Holt, C. S. Cockram, A. Flyvbjerg and B. J. Goldstein), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444324808.ch39

Editor Information

  1. 5

    Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton, UK

  2. 6

    Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China

  3. 7

    Department of Endocrinology and Internal Medicine, The Medical Research Laboratories, Aarhus University Hospital – Aarhus University, Aarhus, Denmark

  4. 8

    Clinical Research, Metabolism Merck Research Laboratories Rahway, NJ, USA

Author Information

  1. 1

    Diabetic Centre, Trieste, Italy

  2. 2

    Danielle Alberti JDRF Centre for Diabetes Complications, Vascular Division–Baker IDI Heart Research Institute, Melbourne, Australia

  3. 3

    Baker IDI Heart and Diabetes Institute, Diabetes Division, Melbourne, Australia

  4. 4

    Monash University, Melbourne, Australia

Publication History

  1. Published Online: 9 JUL 2010
  2. Published Print: 9 JUL 2010

ISBN Information

Print ISBN: 9781405191814

Online ISBN: 9781444324808

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Keywords:

  • Epidemiology of diabetic macrovascular complications;
  • Pathogenesis of diabetic macrovascular disease;
  • Direct effects of vascular AGE accumulation;
  • Studies reducing vascular AGE accumulation;
  • Interaction with the renin angiotensin system;
  • Role of vasoactive hormones in diabetes - related atherosclerosis;
  • RAS and regenerative endothelial cell repair;
  • Role of ET in diabetic macrovascular complications;
  • TNF - related apoptosis inducing ligand and osteoprotegerin;
  • Interventions to reduce diabetes associated macrovascular complications

Summary

This chapter contains sections titled:

  • Epidemiology of diabetic macrovascular complications

  • Pathogenesis of diabetic macrovascular disease

  • Role of vasoactive hormones in diabetes-related atherosclerosis

  • The endothelin system

  • Urotensin II

  • TNF-related apoptosis inducing ligand and osteoprotegerin

  • Complement activation

  • Interventions to reduce diabetes associated macrovascular complications

  • References