Chapter 46. Gastrointestinal Manifestations of Diabetes

  1. Richard I. G. Holt MA, MB BChir, PhD, FRCP, FHEA Professor in Diabetes & Endocrinology2,
  2. Clive S. Cockram MB BS, BSc, MD (Lond), FRCP, FRACP, FHKAM (Med) Emeritus Professor of Medicine3,
  3. Allan Flyvbjerg MD, DMSc Professor of Clinical Endocrinology Chair4 and
  4. Barry J. Goldstein MD, PhD, FACP, FACE Therapeutic Area Head Vice President5
  1. Adil E. Bharucha MD Professor of Medicine and
  2. Michael Camilleri MD

Published Online: 9 JUL 2010

DOI: 10.1002/9781444324808.ch46

Textbook of Diabetes, Fourth Edition

Textbook of Diabetes, Fourth Edition

How to Cite

Bharucha, A. E. and Camilleri, M. (2010) Gastrointestinal Manifestations of Diabetes, in Textbook of Diabetes, Fourth Edition (eds R. I. G. Holt, C. S. Cockram, A. Flyvbjerg and B. J. Goldstein), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444324808.ch46

Editor Information

  1. 2

    Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton, UK

  2. 3

    Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China

  3. 4

    Department of Endocrinology and Internal Medicine, The Medical Research Laboratories, Aarhus University Hospital – Aarhus University, Aarhus, Denmark

  4. 5

    Clinical Research, Metabolism Merck Research Laboratories Rahway, NJ, USA

Author Information

  1. Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA

Publication History

  1. Published Online: 9 JUL 2010
  2. Published Print: 9 JUL 2010

ISBN Information

Print ISBN: 9781405191814

Online ISBN: 9781444324808



  • Normal gastrointestinal motor functions;
  • Pathophysiology of diabetic enteropathy: insights from animal studies;
  • Pathophysiology of diabetic enteropathy in humans;
  • Dyspepsia and gastroparesis;
  • Clinical manifestations;
  • Dysphagia and heartburn;
  • Diarrhea and constipation;
  • Gastroparesis and dyspepsia;
  • Food and Drug Administration (FDA)


This chapter contains sections titled:

  • Introduction

  • Epidemiology

  • Pathophysiology

  • Pathophysiology of diabetic enteropathy in humans

  • Clinical manifestations

  • Diagnostic tests

  • Management

  • References