Chapter 59. Future Drug Treatment for Type 1 Diabetes

  1. Richard I. G. Holt MA, MB BChir, PhD, FRCP, FHEA Professor in Diabetes & Endocrinology2,
  2. Clive S. Cockram MB BS, BSc, MD (Lond), FRCP, FRACP, FHKAM (Med) Emeritus Professor of Medicine3,
  3. Allan Flyvbjerg MD, DMSc Professor of Clinical Endocrinology Chair4 and
  4. Barry J. Goldstein MD, PhD, FACP, FACE Therapeutic Area Head Vice President5
  1. Helena Elding Larsson MD, PhD,
  2. Ahmed J. Delli MD, MPH,
  3. Sten-A. Ivarsson MD, PhD and
  4. Åke Lernmark PhD Professor of Experimental Diabetes

Published Online: 9 JUL 2010

DOI: 10.1002/9781444324808.ch59

Textbook of Diabetes, Fourth Edition

Textbook of Diabetes, Fourth Edition

How to Cite

Larsson, H. E., Delli, A. J., Ivarsson, S.-A. and Lernmark, Å. (2010) Future Drug Treatment for Type 1 Diabetes, in Textbook of Diabetes, Fourth Edition (eds R. I. G. Holt, C. S. Cockram, A. Flyvbjerg and B. J. Goldstein), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444324808.ch59

Editor Information

  1. 2

    Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton, UK

  2. 3

    Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China

  3. 4

    Department of Endocrinology and Internal Medicine, The Medical Research Laboratories, Aarhus University Hospital – Aarhus University, Aarhus, Denmark

  4. 5

    Clinical Research, Metabolism Merck Research Laboratories Rahway, NJ, USA

Author Information

  1. Lund University/Clinical Research Center, Department of Clinical Sciences, University Hospital MAS, Malmö, Sweden

Publication History

  1. Published Online: 9 JUL 2010
  2. Published Print: 9 JUL 2010

ISBN Information

Print ISBN: 9781405191814

Online ISBN: 9781444324808



  • Short history of type 1 diabetes prevention trials;
  • first - degree relatives (FDR);
  • first - phase insulin release (FPIR);
  • glutamic acid decarboxylase (GAD65);
  • intravenous glucose tolerance test (IVGTT);
  • oral glucose tolerance test (OGTT);
  • Primary prevention trials;
  • Prevention and intervention;
  • Intervention (tertiary prevention) trials;
  • Nutritional Intervention to Prevent Diabetes study


This chapter contains sections titled:

  • Introduction

  • Short history of type 1 diabetes prevention trials

  • Prediction

  • Prevention and interventio

  • Future directions

  • References