Chapter 25. Autoimmune Liver Diseases

  1. Nicholas J. Talley MD, PhD Pro Vice Chancellor Professor Adjunct Professor Foreign Adjunct Professor1,2,3,4,5,
  2. Keith D. Lindor MD Dean Professor of Medicine Consultant2,6,7 and
  3. Hugo E. Vargas MD Professor of Medicine Chair Consultant8,9
  1. Jayant A. Talwalkar MD, MPH Associate Professor7 and
  2. Keith D. Lindor MD Dean Professor of Medicine Consultant2,6,7

Published Online: 30 AUG 2010

DOI: 10.1002/9781444325249.ch25

Practical Gastroenterology and Hepatology: Liver and Biliary Disease

Practical Gastroenterology and Hepatology: Liver and Biliary Disease

How to Cite

Talwalkar, J. A. and Lindor, K. D. (2010) Autoimmune Liver Diseases, in Practical Gastroenterology and Hepatology: Liver and Biliary Disease (eds N. J. Talley, K. D. Lindor and H. E. Vargas), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444325249.ch25

Editor Information

  1. 1

    University of Newcastle, NSW, Australia

  2. 2

    College of Medicine, Mayo Clinic, Rochester, MN, USA

  3. 3

    College of Medicine, Mayo Clinic, Jacksonville, FL, USA

  4. 4

    Karolinska Institute, Stockholm, Sweden

  5. 5

    University of North Carolina, USA

  6. 6

    Mayo Medical School, Rochester, MN, USA

  7. 7

    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA

  8. 8

    Division of Hepatology, College of Medicine, Mayo Clinic, Scottsdale, AZ, USA

  9. 9

    Division of Hepatology and Gastroenterology, Mayo Clinic, Scottsdale, AZ, USA

Author Information

  1. 2

    College of Medicine, Mayo Clinic, Rochester, MN, USA

  2. 6

    Mayo Medical School, Rochester, MN, USA

  3. 7

    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA

Publication History

  1. Published Online: 30 AUG 2010
  2. Published Print: 17 SEP 2010

ISBN Information

Print ISBN: 9781405182751

Online ISBN: 9781444325249

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Keywords:

  • Autoimmune Hepatitis;
  • Primary Biliary Cirrhosis;
  • Overlap Syndrome with Autoimmune Hepatitis;
  • Therapeutics: Disease - Related Complications;
  • Therapeutics: Primary Underlying Disease;
  • Treatment End Points

Summary

Autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis are considered the most common autoimmune liver diseases. While the underlying etiopathogenesis for these disorders are considered diverse, the clinical and biochemical presentations can be similar with histological findings in some cases overlapping between disorders. The purpose of this overview is to describe advances in the diagnosis and management of autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis and celiac disease affecting the liver. In addition to discussing criteria which may suggest an overlap between autoimmune hepatitis with either primary biliary cirrhosis or sclerosing cholangitis, practical approaches to therapy for individual diseases will also be presented.