13. Genetic Associations in Schizophrenia

  1. Daniel R. Weinberger MD2 and
  2. Paul J. Harrison MA, BM, BCh, DM(Oxon), FRCPsych3
  1. Michael C. O'Donovan FRCPsych, PhD and
  2. Michael J. Owen FRCPsych, PhD

Published Online: 8 MAR 2011

DOI: 10.1002/9781444327298.ch13

Schizophrenia, Third Edition

Schizophrenia, Third Edition

How to Cite

O'Donovan, M. C. and Owen, M. J. (2010) Genetic Associations in Schizophrenia, in Schizophrenia, Third Edition (eds D. R. Weinberger and P. J. Harrison), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444327298.ch13

Editor Information

  1. 2

    Genes, Cognition and Psychosis Program, Clinical Studies Section, Clinical Brain Disorders Branch, National Institute of Health, Bethesda, MD, USA

  2. 3

    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK

Author Information

  1. Department of Psychological Medicine, UKMRC Centre for Neuropsychiatric Genetics and Genomics, Department, of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 10 DEC 2010

ISBN Information

Print ISBN: 9781405176972

Online ISBN: 9781444327298

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Keywords:

  • schizophrenia;
  • psychosis;
  • allele;
  • SNP;
  • haplotype;
  • linkage disequilibrium;
  • genome-wide association;
  • GWAS;
  • candidate gene;
  • copy number variant;
  • CNV

Summary

Association studies in schizophrenia and other complex disorders have evolved from the earliest studies of one or two markers in functional candidate genes to systematic analyses at a genome-wide level. Here we discuss the principles of association, the meaning of positive and negative findings, and summarize what are, in our judgment, some of most promising findings. We show that genetic studies of schizophrenia are bearing fruit, and are providing new avenues for research into the pathophysiology of this poorly understood disorder.