17. Functional Brain Imaging in Schizophrenia

  1. Daniel R. Weinberger MD3 and
  2. Paul J. Harrison MA, BM, BCh, DM(Oxon), FRCPsych4
  1. Andreas Meyer-Lindenberg MD, PhD, MSc1 and
  2. Edward T. Bullmore PhD, FRCP, FRCPsych, FMedSci2

Published Online: 8 MAR 2011

DOI: 10.1002/9781444327298.ch17

Schizophrenia, Third Edition

Schizophrenia, Third Edition

How to Cite

Meyer-Lindenberg, A. and Bullmore, E. T. (2010) Functional Brain Imaging in Schizophrenia, in Schizophrenia, Third Edition (eds D. R. Weinberger and P. J. Harrison), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444327298.ch17

Editor Information

  1. 3

    Genes, Cognition and Psychosis Program, Clinical Studies Section, Clinical Brain Disorders Branch, National Institute of Health, Bethesda, MD, USA

  2. 4

    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK

Author Information

  1. 1

    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany

  2. 2

    Department of Psychiatry, University of Cambridge, Cambridge, UK

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 10 DEC 2010

ISBN Information

Print ISBN: 9781405176972

Online ISBN: 9781444327298



  • functional brain imaging in schizophrenia;
  • imaging neurocognitive functions;
  • patients with schizophrenia - exhibiting psychomotor disturbances;
  • visual information processing - neuropsychological research, confirming presence of visual information processing deficits in schizophrenia;
  • continuous performance test (CPT) - a terminological label than a standardized test device;
  • “executive cognition”, the delayed match-to-sample, n-back, AX-CPT, and Stroop tasks;
  • emotional dysfunction - central feature of schizophrenia;
  • imaging systems - and connectivity;
  • Hippocampal connectivity;
  • multivariate characterizations of connectivity


In the preceding two decades, functional neuroimaging has emerged as a pivotal tool for schizophrenia research. Techniques such as magnetic resonance imaging (MRI) make available spatiotemporally highly resolved data that can characterize brain function across all stages of the disorder, helping bridge the gap between genetic and molecular mechanisms and psychological and behavioral phenomena by characterizing brain dysfunction underlying psychiatric disorders on the neural systems level. In addition to studying regional dysfunction, systems-level approaches to study functional interactions (“connectivity”) are increasingly important. This chapter reviews important fMRI studies in neurocognitive domains relevant for schizophrenia, such as motor, visual, auditory, attentional, working memory, episodic memory, reward/salience, and social processing, followed by a discussion of the neurobiology of core schizophrenia symptoms (delusions and hallucinations), functional imaging effects of treatment in schizophrenia, and finally findings in subjects at high genetic or clinical risk for the disorder.