19. Neurodevelopmental Origins of Schizophrenia

  1. Daniel R. Weinberger MD2,
  2. Paul J. Harrison MA, BM, BCh, DM(Oxon), FRCPsych3
  1. Daniel R. Weinberger MD2,
  2. Pat Levitt PhD1

Published Online: 8 MAR 2011

DOI: 10.1002/9781444327298.ch19

Book Title

Schizophrenia, Third Edition

Schizophrenia, Third Edition

Additional Information

How to Cite

Weinberger, D. R. and Levitt, P. (2011) Neurodevelopmental Origins of Schizophrenia, in Schizophrenia, Third Edition (eds D. R. Weinberger and P. J. Harrison), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444327298.ch19

Editor Information

  1. 2

    Genes, Cognition and Psychosis Program, Clinical Studies Section, Clinical Brain Disorders Branch, National Institute of Health, Bethesda, MD, USA

  2. 3

    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK

Author Information

  1. 1

    Department of Cell & Neurobiology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA

  2. 2

    Genes, Cognition and Psychosis Program, Clinical Studies Section, Clinical Brain Disorders Branch, National Institute of Health, Bethesda, MD, USA

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 10 DEC 2010

ISBN Information

Print ISBN: 9781405176972

Online ISBN: 9781444327298

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CHAPTER TOOLS

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Keywords:

  • neurodevelopmental origins of schizophrenia;
  • neurodevelopment hypothesis of schizophrenia - alternative to neurotransmitter hypotheses;
  • three theoretical pillars of neurodevelopmental view of schizophrenia;
  • genes, objective causative factors - not the only factors;
  • evidence that abnormal brain development increases risk;
  • association with maturational deficits and delays in childhood;
  • epistatic interactions of genes - in NRG1/ERBB4/AKT1 signaling pathway;
  • metachromatic leukodystrophy (MLD), rare genetic disorder - of aryl sulfatase deficiency;
  • Candidate maturational processes and psychosis onset;
  • major mysteries about schizophrenia - barely addressed by existing research data

Summary

This chapter contains sections titled:

  • Introduction

  • What is the evidence that abnormal brain development increases risk?

  • Clues to a molecular mechanism of developmental deviation

  • Why do the clinical manifestations of schizophrenia change over time?

  • Relevant biological events in adolescent brain development

  • Candidate maturational processes and psychosis onset

  • Conclusions

  • References

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