2. The Schizophrenia Construct: Symptomatic Presentation

  1. Daniel R. Weinberger MD3 and
  2. Paul J. Harrison MA, BM, BCh, DM(Oxon), FRCPsych4
  1. Celso Arango MD, PhD1 and
  2. William T. Carpenter MD2

Published Online: 8 MAR 2011

DOI: 10.1002/9781444327298.ch2

Schizophrenia, Third Edition

Schizophrenia, Third Edition

How to Cite

Arango, C. and Carpenter, W. T. (2010) The Schizophrenia Construct: Symptomatic Presentation, in Schizophrenia, Third Edition (eds D. R. Weinberger and P. J. Harrison), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444327298.ch2

Editor Information

  1. 3

    Genes, Cognition and Psychosis Program, Clinical Studies Section, Clinical Brain Disorders Branch, National Institute of Health, Bethesda, MD, USA

  2. 4

    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK

Author Information

  1. 1

    Department of Psychiatry, Hospital General Universitario Gregorio Marañon, Cibersam, Madrid, Spain

  2. 2

    University of Maryland School of Medicine, Baltimore, MD, USA

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 10 DEC 2010

ISBN Information

Print ISBN: 9781405176972

Online ISBN: 9781444327298



  • schizophrenia;
  • symptoms;
  • cognition;
  • negative symptoms;
  • psychopathology;
  • paradigm shift;
  • DSM-V;
  • domains of pathology;
  • psychosis


The schizophrenia construct represents a clinical syndrome with substantial variation between individuals receiving this diagnosis. Psychotic features, such as hallucinations and delusions, and, to a lesser extent, disorganization of thought are common across cases. Other features such as avolitional pathology and impaired cognition are critical to functional outcomes and represent core pathologies, but are less critical for diagnosis. A paradigm shift from schizophrenia as a disease entity to domains of pathology within the syndrome has occurred. Implications are profound and include an approach to dimensions that may represent the critical advance in the preparation of DSM-V and ICD-11 diagnostic manuals.