4. Late-Onset Schizophrenia

  1. Daniel R. Weinberger MD4 and
  2. Paul J. Harrison MA, BM, BCh, DM(Oxon), FRCPsych5
  1. Robert Howard MD, MRCPsych1 and
  2. Dilip Jeste MD2,3

Published Online: 8 MAR 2011

DOI: 10.1002/9781444327298.ch4

Schizophrenia, Third Edition

Schizophrenia, Third Edition

How to Cite

Howard, R. and Jeste, D. (2010) Late-Onset Schizophrenia, in Schizophrenia, Third Edition (eds D. R. Weinberger and P. J. Harrison), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444327298.ch4

Editor Information

  1. 4

    Genes, Cognition and Psychosis Program, Clinical Studies Section, Clinical Brain Disorders Branch, National Institute of Health, Bethesda, MD, USA

  2. 5

    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK

Author Information

  1. 1

    Department of Old Age Psychiatry, Institute of Psychiatry, King's College London, London, UK

  2. 2

    Division of Geriatric Psychiatry, University of California; VA San Diego Healthcare System, San Diego, CA, USA

  3. 3

    Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, CA, USA

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 10 DEC 2010

ISBN Information

Print ISBN: 9781405176972

Online ISBN: 9781444327298



  • late-onset schizophrenia - contentious area from clinical and research viewpoints;
  • important questions, having ICD-10 and DSM-IV-TR;
  • late paraphrenia, within ICD-9 - not surviving as a separate codeable diagnosis in ICD-10;
  • very late-onset schizophrenia-like psychosis (VLOSLP);
  • affective symptoms - affective features in late-onset schizophrenia, recognized clinically;
  • brain abnormalities - seen with imaging;
  • sensory deficits, deafness - clinically associated with paranoid symptoms;
  • premorbid personality in patients - late and mid-life paranoid psychoses, quality of premorbid relationships within families;
  • antipsychotic medications, effective symptomatic treatment - for early- and late-onset;
  • differences, patients with early- and late-onset schizophrenia - late-onset condition, neurobiologically distinct subtype


This chapter contains sections titled:

  • Historical background and approaches to classification

  • Clinical features

  • Etiology

  • Management

  • Conclusions

  • Acknowledgement

  • References