6. The Prodrome of Schizophrenia

  1. Daniel R. Weinberger MD3 and
  2. Paul J. Harrison MA, BM, BCh, DM(Oxon), FRCPsych4
  1. Jean Addington PhD1 and
  2. Shôn W. Lewis MD, FMedSci2

Published Online: 8 MAR 2011

DOI: 10.1002/9781444327298.ch6

Schizophrenia, Third Edition

Schizophrenia, Third Edition

How to Cite

Addington, J. and Lewis, S. W. (2010) The Prodrome of Schizophrenia, in Schizophrenia, Third Edition (eds D. R. Weinberger and P. J. Harrison), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444327298.ch6

Editor Information

  1. 3

    Genes, Cognition and Psychosis Program, Clinical Studies Section, Clinical Brain Disorders Branch, National Institute of Health, Bethesda, MD, USA

  2. 4

    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK

Author Information

  1. 1

    Department of Psychiatry, Alberta Mental Health Centennial Research Chair, Novartis Chair in Schizophrenia Research, University of Calgary, Canada

  2. 2

    University of Manchester, Manchester, UK

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 10 DEC 2010

ISBN Information

Print ISBN: 9781405176972

Online ISBN: 9781444327298



  • prodromal;
  • dopamine;
  • antipsychotic drugs;
  • cognitive therapy


Prodromal symptoms of schizophrenia, or an at-risk mental state, can be reliably identified. People seeking help for such symptoms have a 15–30% increased risk of developing psychosis over the next 12 months. Continuities have been shown with the psychology and biology of full psychosis. Drug and cognitive treatments may be effective.