8. Neurocognitive Impairments in Schizophrenia: Their Character and Role in Symptom Formation

  1. Daniel R. Weinberger MD4 and
  2. Paul J. Harrison MA, BM, BCh, DM(Oxon), FRCPsych5
  1. Terry E. Goldberg PhD1,
  2. Anthony David MD, FRCP, FRCPsych, MSc2 and
  3. James. M. Gold PhD3

Published Online: 8 MAR 2011

DOI: 10.1002/9781444327298.ch8

Schizophrenia, Third Edition

Schizophrenia, Third Edition

How to Cite

Goldberg, T. E., David, A. and Gold, James. M. (2010) Neurocognitive Impairments in Schizophrenia: Their Character and Role in Symptom Formation, in Schizophrenia, Third Edition (eds D. R. Weinberger and P. J. Harrison), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444327298.ch8

Editor Information

  1. 4

    Genes, Cognition and Psychosis Program, Clinical Studies Section, Clinical Brain Disorders Branch, National Institute of Health, Bethesda, MD, USA

  2. 5

    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK

Author Information

  1. 1

    Albert Einstein College of Medicine Zucker Hillside Hospital/Litwin Zucker Alzheimer's Disease Research Center Feinstein Institute for Medical Research Manhasset, NY, USA

  2. 2

    Institute of Psychiatry, King's College, London, London, UK

  3. 3

    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Crownsville, MD, USA

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 10 DEC 2010

ISBN Information

Print ISBN: 9781405176972

Online ISBN: 9781444327298



  • neurocognitive impairments in schizophrenia - character and role in symptom formation;
  • abnormalities in attentional, associative and volitional cognitive processes - features of schizophrenia, since Kraepelin and Bleuler;
  • Wechsler Adult Intelligence Scale (WAIS) and Halstead–Reitan measures;
  • experimental approaches - to study of specific cognitive functions in schizophrenia;
  • episodic memory, and observations - evidence of anatomical abnormalities in hippocampus, role in normal memory function;
  • working memory, maintaining representations - in activated, ongoing behavior and cognitive processing;
  • attention, “elastic” concept in schizophrenia literature - clinical observations;
  • cognition, functional outcome - and cognitive effects of antipsychotics;
  • Chris Frith (1992), first to suggest a theory of mind (ToM) - inferring another's mental state, beliefs, desires, intentions and delusions;
  • cognitive paradigms, constraining thinking - about schizophrenia, and what is “wrong” with patients


This chapter contains sections titled:

  • Introduction

  • Course of cognitive impairment

  • Tradition of clinical neuropyschological studies of schizophrenia

  • Experimental approaches to the study of specific cognitive functions in schizophrenia

  • Cognition, functional outcome, and the cognitive effects of antipsychotics

  • Neuropsychological investigations of psychotic symptoms

  • Conclusions

  • References