15. Acute Lymphoblastic Leukemia: Presentation, Diagnosis and Classification

  1. Stefan Faderl MD Associate Professor and
  2. Hagop Kantarjian MD Chairman Professor
  1. Sandeep Gurbuxani and
  2. John Anastasi

Published Online: 4 JAN 2011

DOI: 10.1002/9781444327359.ch15

Leukemias: Principles and Practice of Therapy

Leukemias: Principles and Practice of Therapy

How to Cite

Gurbuxani, S. and Anastasi, J. (2010) Acute Lymphoblastic Leukemia: Presentation, Diagnosis and Classification, in Leukemias: Principles and Practice of Therapy (eds S. Faderl and H. Kantarjian), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444327359.ch15

Editor Information

  1. Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX, USA

Author Information

  1. Section of Hematopathology, Department of Pathology, University of Chicago, Chicago, Illinois, USA

Publication History

  1. Published Online: 4 JAN 2011
  2. Published Print: 26 NOV 2010

ISBN Information

Print ISBN: 9781405182355

Online ISBN: 9781444327359

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Keywords:

  • acute leukemia;
  • lymphoblastic;
  • epidemiology;
  • presentation;
  • diagnosis;
  • morphology;
  • immunophenotype;
  • molecular genetics

Summary

Acute lymphoblastic leukemia (ALL) of B- or T-cell type requires a precise and rapid diagnosis and careful subclassification so that appropriate therapy can be instituted. In this chapter, the epidemiology, presentation, and diagnostic features of ALL are reviewed. This includes the morphologic characteristics of ALL in the peripheral blood, bone marrow aspirate, and biopsy sections, along with its immunophenotypic profile obtained through multiparameter flow cytometry. The differential diagnosis is briefly discussed, followed by a review of the cytogenetic and molecular characteristics currently used for subclassification.