17. Salvage Therapy of Adult Acute Lymphoblastic Leukemia

  1. Stefan Faderl MD Associate Professor and
  2. Hagop Kantarjian MD Chairman Professor
  1. Nicola Gökbuget MD Head1 and
  2. Dieter Hoelzer MD2

Published Online: 4 JAN 2011

DOI: 10.1002/9781444327359.ch17

Leukemias: Principles and Practice of Therapy

Leukemias: Principles and Practice of Therapy

How to Cite

Gökbuget, N. and Hoelzer, D. (2010) Salvage Therapy of Adult Acute Lymphoblastic Leukemia, in Leukemias: Principles and Practice of Therapy (eds S. Faderl and H. Kantarjian), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444327359.ch17

Editor Information

  1. Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX, USA

Author Information

  1. 1

    Goethe University Hospital, Department of Medicine II, Hematology/Oncology, Frankfurt, Germany

  2. 2

    Professor of Internal Medicine, Onkologikum am Museumsufer, Frankfurt, Germany

Publication History

  1. Published Online: 4 JAN 2011
  2. Published Print: 26 NOV 2010

ISBN Information

Print ISBN: 9781405182355

Online ISBN: 9781444327359

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Keywords:

  • acute lymphoblastic leukemia (ALL);
  • relapse;
  • salvage;
  • chemotherapy;
  • new drugs;
  • stem cell transplantation;
  • minimal residual disease

Summary

Overall outcome of adult ALL has improved significantly in the past decades, but the survival after relapse is still extremely poor (at around 5% in several large retrospective studies). Although the major aim is to avoid relapse by improved front-line therapies, optimization of salvage therapy is a pre-requisite for improvement of overall survival. Results of retrospective and prospective studies for chemotherapy and stem cell transplantation will be reviewed, as well as approaches for rational selection and evaluation of salvage therapies.