32. Management of Infectious Complications in Patients with Leukemia

  1. Stefan Faderl MD Associate Professor and
  2. Hagop Kantarjian MD Chairman Professor
  1. Marcio Nucci MD1,2,
  2. Nair Bijay2 and
  3. Elias Anaissie2

Published Online: 4 JAN 2011

DOI: 10.1002/9781444327359.ch32

Leukemias: Principles and Practice of Therapy

Leukemias: Principles and Practice of Therapy

How to Cite

Nucci, M., Bijay, N. and Anaissie, E. (2010) Management of Infectious Complications in Patients with Leukemia, in Leukemias: Principles and Practice of Therapy (eds S. Faderl and H. Kantarjian), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444327359.ch32

Editor Information

  1. Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX, USA

Author Information

  1. 1

    University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

  2. 2

    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Publication History

  1. Published Online: 4 JAN 2011
  2. Published Print: 26 NOV 2010

ISBN Information

Print ISBN: 9781405182355

Online ISBN: 9781444327359

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Keywords:

  • leukemia;
  • complication;
  • infection;
  • supportive care;
  • management;
  • diagnosis

Summary

Infections represent a leading complication in patients with leukemia, and they occur as a result of various impairments in host defenses caused by both the disease itself and its treatment. Infections can cause serious complications, including treatment delays and even death. Critical to the management of infectious complications in patients with leukemia is the recognition of the heterogeneity of the patient population and the understanding of the various defects in host defenses and likely infections associated with each type of leukemia and treatment applied. In this chapter, we discuss the epidemiology of and risk factors for different infections, the important pathogens that cause serious infection in patients with leukemia, and the most common infectious syndromes observed. We also present the special risk features for infection in the different types of leukemia. The management of infections, including diagnosis, prophylaxis and treatment, is also discussed.