4. Integration of Metabolism 2: Macronutrients

  1. Dr Susan A Lanham-New3,
  2. Professor Ian A Macdonald4 and
  3. Associate Professor Helen M Roche5
  1. Professor Keith N Frayn1 and
  2. Professor Abayomi O Akanji2

Published Online: 16 MAR 2011

DOI: 10.1002/9781444327779.ch4

Nutrition and Metabolism, Second Edition

Nutrition and Metabolism, Second Edition

How to Cite

Frayn, K. N. and Akanji, A. O. (2010) Integration of Metabolism 2: Macronutrients, in Nutrition and Metabolism, Second Edition (eds S. A. Lanham-New, I. A. Macdonald and H. M. Roche), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444327779.ch4

Editor Information

  1. 3

    University of Surrey, UK

  2. 4

    University of Nottingham, UK

  3. 5

    University College Dublin, Ireland

Author Information

  1. 1

    Oxford University, UK

  2. 2

    Kuwait University, Kuwait

Publication History

  1. Published Online: 16 MAR 2011
  2. Published Print: 19 NOV 2010

ISBN Information

Print ISBN: 9781405168083

Online ISBN: 9781444327779



  • metabolism 2 integration and macronutrients;
  • human body, a machine - taking in fuel, converting to useful forms of energy;
  • energy intake pattern, sporadic - with regular, discrete meals;
  • macronutrient stores and fuel daily flow;
  • macronutrient flux short-term regulation;
  • body needs mechanisms - individual macronutrient regulating flow;
  • macronutrient flux longer-term regulation;
  • growth hormone, peptide hormone - pituitary gland, and direct metabolic effects on tissues;
  • skeletal muscle, constituting - 40% of body weight;
  • rapid changes in macronutrient metabolism - endogenous fuel mobilisation suppression


This chapter contains sections titled:

  • Introduction: fuel intake and fuel utilisation

  • Regulatory mechanisms

  • Hormones that regulate macronutrient metabolism

  • Macronutrient metabolism in the major organs and tissues

  • Substrate fluxes in the overnight fasting state

  • Postprandial substrate disposal

  • Short-term and longer-term starvation

  • Perspectives on the future

  • Further reading