5. Integration of Metabolism 3: Protein and Amino Acids

  1. Dr Susan A Lanham-New4,
  2. Professor Ian A Macdonald5 and
  3. Associate Professor Helen M Roche6
  1. Dr Margaret E Brosnan1,
  2. Professor John T Brosnan2 and
  3. Dr Vernon R Young3

Published Online: 16 MAR 2011

DOI: 10.1002/9781444327779.ch5

Nutrition and Metabolism, Second Edition

Nutrition and Metabolism, Second Edition

How to Cite

Brosnan, M. E., Brosnan, J. T. and Young, V. R. (2010) Integration of Metabolism 3: Protein and Amino Acids, in Nutrition and Metabolism, Second Edition (eds S. A. Lanham-New, I. A. Macdonald and H. M. Roche), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444327779.ch5

Editor Information

  1. 4

    University of Surrey, UK

  2. 5

    University of Nottingham, UK

  3. 6

    University College Dublin, Ireland

Author Information

  1. 1

    Memorial Hospital of Newfoundland, Canada

  2. 2

    University of Newfoundland, Canada

  3. 3

    Formally of MIT, USA

Publication History

  1. Published Online: 16 MAR 2011
  2. Published Print: 19 NOV 2010

ISBN Information

Print ISBN: 9781405168083

Online ISBN: 9781444327779

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Keywords:

  • integration of metabolism 3 - protein and amino acids;
  • protein and amino acid metabolism - large-scale, dynamic and regulated processes;
  • amino acid and protein metabolism integration - within organisms;
  • protein synthesis and turnover - nature and regulation;
  • amino acid metabolism, examples of interorgan process - and physiological goals;
  • translation phase of protein synthesis regulation;
  • elongation phase, following - initiation complex formation;
  • post-translational modifications - versatility to genome;
  • interorgan amino acid metabolism;
  • physiological function - and amino acid and peptide transport regulation

Summary

This chapter contains sections titled:

  • Introduction

  • Protein and amino acid turnover

  • Protein synthesis

  • Regulation of the translation phase of protein synthesis

  • Post-translational events

  • Protein degradation

  • Selectivity of protein turnover

  • An integration of these processes of turnover with respect to amino acid metabolism

  • Regulation of amino acid metabolism

  • Amino acid synthesis: the dispensable amino acids

  • In vivo aspects of protein and amino acid turnover

  • In vivo rates of protein turnover

  • Mechanisms and factors responsible for alterations in protein turnover

  • Interorgan amino acid metabolism

  • Amino acid and peptide transport

  • Disposal of dietary amino acids and roles of specific organs

  • Catabolic illnesses

  • Non-proteinogenic metabolic functions of amino acids

  • Perspectives on the future

  • Further reading