Chapter 1. Routine Cerebrospinal Fluid (CSF) Analysis

  1. Nils Erik Gilhus MD, PhD Professor9,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director10 and
  3. Michael Brainin MD Professor11
  1. F. Deisenhammer1,
  2. A. Bartos2,
  3. R. Egg3,4,
  4. N. E. Gilhus MD, PhD Professor9,
  5. G. Giovannoni5,
  6. S. Rauer6,
  7. F. Sellebjerg7 and
  8. H. Tumani8

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch1

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Routine Cerebrospinal Fluid (CSF) Analysis, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch1

Author Information

  1. 9

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 10

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 11

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    Innsbruck Medical University, Austria

  2. 2

    Charles University, Prague, Czech Republic, UK

  3. 3

    University of Bergen, Norway

  4. 4

    Haukeland University Hospital, Bergen, Norway

  5. 5

    University College London, Queen Square, London, UK

  6. 6

    Albert-Ludwigs University, Freiburg, Germany

  7. 7

    Copenhagen University Hospital, Denmark

  8. 8

    University of Ulm, Germany

  9. 9

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394

SEARCH

Keywords:

  • routine cerebrospinal fluid (CSF) analysis - CSF, dynamic, metabolically active substance having many important functions;
  • CSF, obtained with relative ease by lumbar puncture (LP);
  • quantitative analysis of total protein and albumin;
  • blood–CSF barrier, a physical barrier consisting of different anatomical structures;
  • CSF to serum albumin concentration quotient (Qalb) - to evaluate blood–CSF barrier integrity;
  • intrathecal Ig synthesis, in mainly inflammatory CNS diseases;
  • detection of intrathecal oligoclonal IgG in CSF - useful diagnostically;
  • CSF, an ultrafiltrate of plasma, containing immunoglobulins - passively transferred from plasma;
  • CSF glucose concentration - CSF/serum glucose ratio and lactate;
  • quality assurance in CSF diagnostics

Summary

This chapter contains sections titled:

  • Introduction

  • Search strategy

  • Quantitative analysis of total protein and albumin

  • Qualitative (oligoclonal) intrathecal IgG synthesis

  • Quantitative intrathecal immunoglobulin synthesis

  • CSF glucose concentration, CSF/serum glucose ratio and lactate

  • Cytological examination

  • Investigation of infectious CSF

  • Quality assurance in CSF diagnostics

  • References