Chapter 10. Drug Treatment of Migraine

  1. Nils Erik Gilhus MD, PhD Professor9,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director10 and
  3. Michael Brainin MD Professor11
  1. S. Evers1,
  2. J. Áfra2,
  3. A. Frese1,3,
  4. P. J. Goadsby4,5,
  5. M. Linde6,
  6. A. May7 and
  7. P. S. S´ndor8

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch10

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Drug Treatment of Migraine, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch10

Author Information

  1. 9

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 10

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 11

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    University of Münster, Germany

  2. 2

    National Institute of Neurosurgery, Budapest, Hungary

  3. 3

    Academy of Manual Medicine, Münster, Germany

  4. 4

    University of California, San Francisco CA, USA

  5. 5

    UCL, Institute of Neurology, Queen Square, London, UK

  6. 6

    Cephalea Headache Centre, Läkarhuset Södra vägen, Gothenburg, Sweden

  7. 7

    University of Hamburg, Germany

  8. 8

    University of Zurich, Switzerland

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • drug treatment of migraine;
  • guidelines, evidence-based recommendations - for drug treatment of migraine attacks and migraine prophylaxis;
  • databases - MEDLINE, Science Citation Index and the Cochrane Library;
  • migraine attacks and migraine prophylaxis;
  • antiemetics in acute migraine attacks - for treating nausea and potential emesis;
  • Ergot alkaloids;
  • typical problem of attack treatment in migraine - headache recurrence;
  • triptans, very homogenous group of acute migraine drugs - with respect to efficacy, pharmacology and safety;
  • migraine prophylaxis - prophylactic drug treatment of migraine possible with several drugs;
  • migraine in children and adolescents - ibuprofen, only analgesics with evidence of efficacy for acute migraine treatment in childhood and adolescents


This chapter contains sections titled:

  • Search strategy

  • Method for reaching consensus

  • Objectives

  • Background

  • Diagnosis

  • Clinical aspects

  • Epidemiology

  • Drug treatment of m igraine attacks

  • Migraine prophylaxis

  • Specific situations

  • References