16. Alzheimer's Disease

  1. Nils Erik Gilhus MD, PhD Professor9,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director10 and
  3. Michael Brainin MD Professor11
  1. J. Hort1,
  2. J. T. O'Brien2,
  3. G. Gainotti3,
  4. T. Pirttila4,
  5. B. O. Popescu5,
  6. I. Rektorova6,
  7. S. Sorbi7 and
  8. P. Scheltens8

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch16

European Handbook of Neurological Management, Volume 1, Second Edition

European Handbook of Neurological Management, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Alzheimer's Disease, in European Handbook of Neurological Management, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch16

Author Information

  1. 9

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 10

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 11

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    Charles University in Prague, Second Faculty of Medicine and Motol Hospital, Czech Republic

  2. 2

    Institute for Ageing and Health, Newcastle University, UK

  3. 3

    Policlinico Gemelli/Catholic University, Rome, Italy

  4. 4

    Kuopio University Hospital, Finland

  5. 5

    University Hospital, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania

  6. 6

    Masaryk University and St Anne's Hospital, Brno, Czech Republic

  7. 7

    University of Florence, Italy

  8. 8

    VU University Medical Center, Amsterdam, The Netherlands

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • Alzheimer's disease;
  • European Federation of Neurological Societies (EFNS) recommendations - on diagnosis and management of Alzheimer's disease (AD);
  • Dementia, affecting 5.4% of over-65s - its prevalence further increasing with age;
  • Memory functions Memory - especially episodic memory, systematically assessed (Class I);
  • assessment of activities of daily living;
  • language praxis and visual-spatial abilities - variably affected according to type and stage of dementia;
  • genetics of dementia, complex and genetic testing - associated with ethical concerns;
  • management of Alzheimer's disease;
  • effects on non-cognitive behavioural and psychological symptoms of dementia (BPSD);
  • Memantine, a non-competitive N-Methyl-D–Aspartate (NMDA) receptor antagonist - subject to several RCTs in AD


This chapter contains sections titled:

  • Objectives

  • Background

  • Search strategy

  • Reaching of the consensus

  • Results

  • Management of Alzheimer's disease

  • References