Chapter 19. Autoimmune Neuromuscular Transmission Disorders

  1. Nils Erik Gilhus MD, PhD Professor9,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director10 and
  3. Michael Brainin MD Professor11
  1. G. O. Skeie9,
  2. S. Apostolski1,
  3. A. Evoli2,
  4. N. E. Gilhus MD, PhD Professor9,
  5. I. Illa3,
  6. L. Harms4,
  7. D. Hilton-Jones5,
  8. A. Melms6,
  9. J. Verschuuren7 and
  10. H. Westgaard Horge8

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch19

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Autoimmune Neuromuscular Transmission Disorders, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch19

Author Information

  1. 9

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 10

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 11

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    Institute of Neurology, School of Medicine, University of Belgrade, Serbia and Montenegro

  2. 2

    Catholic University, Rome, Italy

  3. 3

    Hospital Sta Creu i Sant Pau, Barcelona, Spain

  4. 4

    Universitätsmedizin Berlin Charité, Neurologische Klinik Berlin, Germany

  5. 5

    Radcliffe Infirmary, Oxford, UK

  6. 6

    Neurologische Klinik, Universität Tübingen, Germany

  7. 7

    LUMC, Leiden, The Netherlands

  8. 8

    The Norwegian Musculary Disorders Association, Norway

  9. 9

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394

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Keywords:

  • autoimmune neuromuscular transmission disorders;
  • autoimmune neuromuscular transmission (NMT) disorders - relatively rare, often debilitating diseases;
  • Cochrane Central Register of Controlled Trials (CENTRAL) sought;
  • Myasthenia gravis (MG)-MG - characterized by a fluctuating weakness of skeletal muscle with remissions and exacerbations;
  • optimal dose, determined by balance between clinical improvement and adverse effects;
  • intravenous immunoglobulin (IVIg);
  • plasma exchange – antibodies, removed from patient sera by membrane filtration or centrifugation;
  • Thymectomy (TE), surgical approaches to TE - full or partial sternotomy, transcervical and thoracoscopic;
  • Tacrolimus (FK506), a macrolide molecule - of the same immunosuppressant class as ciclosporin;
  • symptomatic and immune-directed treatment

Summary

This chapter contains sections titled:

  • Background and objectives

  • Materials and methods

  • Myasthenia gravis (MG)

  • Lambert-Eaton myasthenic syndrome (LEMS)

  • Neuromyotonia (peripheral nerve hyperexcitability)/Isaacs' syndrome

  • References