Chapter 20. Chronic Inflammatory Demyelinating Polyradiculoneuropathy

  1. Nils Erik Gilhus MD, PhD Professor13,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director14 and
  3. Michael Brainin MD Professor15
  1. P. Y. K. Van den Bergh1,
  2. R. D. M. Hadden2,
  3. Pierre Bouche3,
  4. D. R. Cornblath4,
  5. A. Hahn5,
  6. I. Illa6,
  7. C. L. Koski7,
  8. J.-M. Léger3,
  9. E. Nobile - Orazio8,
  10. J. Pollard9,
  11. C. Sommer10,
  12. P. A. van Doorn11 and
  13. I. N. van Schaik12

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch20

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Chronic Inflammatory Demyelinating Polyradiculoneuropathy, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch20

Author Information

  1. 13

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 14

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 15

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    Centre de Référence Neuromusculaire, Cliniques universitaires St-Luc, Brussels, Belgium

  2. 2

    King's College London School of Medicine, London, UK

  3. 3

    Consultation de Pathologie Neuromusculaire Groupe Hospitalier, Pitié Salpêtriére, Paris, France

  4. 4

    Johns Hopkins University, Baltimore, MD, USA

  5. 5

    London Health Sciences Centre, London, ON, Canada

  6. 6

    Hospital Universitari de la Sta Creu i Sant Pau, Barcelona, Spain

  7. 7

    University of Maryland, School of Medicine, Baltimore, MD, USA

  8. 8

    University of Milan IRCCS Humanitas Clinical Institute, Italy

  9. 9

    University of Sydney, Australia

  10. 10

    University of Würzburg, Germany

  11. 11

    Erasmus Medical Centre, Rotterdam, The Netherlands

  12. 12

    Academic Medical Center, University of Amsterdam, The Netherlands

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394

SEARCH

Keywords:

  • chronic inflammatory demyelinating polyradiculoneuropathy;
  • different sets of diagnostic criteria for CIDP - sensitivity and specificity varying;
  • aim to update EFNS/PNS guideline on management of CIDP - based on newly available evidence;
  • demyelinating polyradiculoneuropathy - and electrodiagnostic criteria;
  • supportive features for diagnosis of CIDP - macrophage–associated demyelination, onion bulb formation, demyelinated and remyelinated nerve fibres;
  • intravenous immunoglobulin - showing that IVIg 2.0 g/kg produces significant improvement in disability lasting 2–6 weeks;
  • Good Practice Points for defining diagnostic criteria for CIDP - initial management;
  • no evidence-based guideline - as none of trials, systematically assessed long-term management;
  • immunosuppressant and immunomodulatory drugs - beneficial in CIDP (Class IV evidence);
  • dearth of evidence, concerning general aspects of treatment for symptoms of CIDP - as pain and fatigue

Summary

This chapter contains sections titled:

  • Objectives

  • Background

  • Search strategy

  • Methods for reaching consensus

  • Results

  • References