Chapter 21. Multifocal Motor Neuropathy

  1. Nils Erik Gilhus MD, PhD Professor12,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director13 and
  3. Michael Brainin MD Professor14
  1. I. N. van Schaik1,
  2. J.- M. Léger2,
  3. E. Nobile - Orazio3,
  4. D. R. Cornblath4,
  5. R. D. M. Hadden5,
  6. C. L. Koski6,
  7. J. Pollard7,
  8. C. Sommer8,
  9. I. Illa9,
  10. P. Van den Bergh10 and
  11. P. A. van Doorn11

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch21

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Multifocal Motor Neuropathy, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch21

Author Information

  1. 12

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 13

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 14

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    Academic Medical Center, University of Amsterdam, The Netherlands

  2. 2

    Hôpital de la Salpêtrière, Paris, France

  3. 3

    University of Milan IRCCS Humanitas Clinical Institute, Italy

  4. 4

    Johns Hopkins University School of Medicine, Baltimore, MD, USA

  5. 5

    King's College Hospital, London, UK

  6. 6

    University of Maryland, Baltimore, MD, USA

  7. 7

    University of Sydney, Australia

  8. 8

    University of Wurzburg, Germany

  9. 9

    Hospital Sta Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain

  10. 10

    Centre de Référence Neuromusculaire, Cliniques universitaires St-Luc, Brussels, Belgium

  11. 11

    Erasmus Medical Center, Rotterdam, The Netherlands

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • multifocal motor neuropathy;
  • EFNS/PNS guideline update - for definition, diagnosis, and treatment of multifocal motor neuropathy (MMN);
  • clinical criteria for MMN;
  • MMN, and differential diagnosis of patient - with a slowly or stepwise progressive asymmetrical limb weakness without objective sensory abnormalities;
  • clinical examination and electrodiagnostic tests – mandatory, suggesting a diagnosis of MMN;
  • supportive criteria and diagnostic categories;
  • GM1 antibodies and definite CB - significantly correlated with favourable response to IVIg;
  • patients, with pure motor, asymmetric neuropathy - and multifocal conduction blocks (CB);
  • MMN, a treatable disorder - effect of immunomodulatory drugs;
  • task force offered advice as Good Practice Points (GPP)


This chapter contains sections titled:

  • Objectives

  • Background

  • Search strategy

  • Methods for reaching consensus

  • Results

  • References