Chapter 24. Neurological Complications of HIV Infection

  1. Nils Erik Gilhus MD, PhD Professor9,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director10 and
  3. Michael Brainin MD Professor11
  1. P. Portegies1,
  2. P. Cinque2,
  3. A. Chaudhuri3,
  4. J. Begovac4,
  5. I. Everall5,
  6. T. Weber6,
  7. M. Bojar7,
  8. P. Martinez - Martin8 and
  9. P. G. E. Kennedy3

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch24

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Neurological Complications of HIV Infection, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch24

Author Information

  1. 9

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 10

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 11

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    OLVG Hospital Amsterdam, The Netherlands

  2. 2

    San Raffaele Hospital, Milano, Italy

  3. 3

    University of Glasgow, Scotland, UK

  4. 4

    University of Zagreb, Croatia

  5. 5

    Institute of Psychiatry, London, UK

  6. 6

    Marienkrankenhaus, Hamburg, Germany

  7. 7

    Motol Hospital, Prague, Czech Republic

  8. 8

    National Center for Epidemiology, Carlos 111 Institute of Health, Spain

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • infections, 24 neurological complications of HIV infection;
  • highly active antiretroviral therapy (HAART) - for treatment of HIV infection;
  • HIV infection, in new populations - and neurological complications, frequent in patients who are not adequately treated and are immunosuppressed;
  • neurological diseases, more directly related to HIV itself - are HIV dementia, vacuolar myelopathy and peripheral neuropathy;
  • cerebral toxoplasmosis, frequent cause of focal brain disease in HIV infection;
  • progressive multifocal leukoencephalopathy (PML) - viral opportunistic infection of oligodendrocytes and astrocytes leading to demyelination in CNS;
  • infection with yeast Cryptococcus neoformans in HIV-infected individuals - leading to subacute meningitis;
  • HIV myelopathy;
  • HAART, improves neurological status - prolonging survival in patients with primary CNS lymphoma;
  • immune reconstitution inflamatory syndrome (IRIS)


This chapter contains sections titled:

  • Background and objectives

  • Neurological complications


  • Search strategy

  • Grading of recommendations

  • Summary and conclusions

  • References