25. Viral Meningo-Encephalitis

  1. Nils Erik Gilhus MD, PhD Professor8,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director9 and
  3. Michael Brainin MD Professor10
  1. I. Steiner1,2,3,
  2. H. Budka3,
  3. A. Chaudhuri4,
  4. M. Koskiniemi5,
  5. K. Sainio6,
  6. O. Salonen6 and
  7. P. G. E. Kennedy7

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch25

European Handbook of Neurological Management, Second Edition

European Handbook of Neurological Management, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Viral Meningo-Encephalitis, in European Handbook of Neurological Management, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch25

Author Information

  1. 8

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 9

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 10

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    Rabin Medical Center, Petach Tiqva, Israel

  2. 2

    Hadassah University Hospital, Jerusalem, Israel

  3. 3

    Institute of Neurology, Medical University of Vienna, Austria

  4. 4

    Essex Centre for Neurological Sciences, Queen's Hospital, Romford, UK

  5. 5

    Haartman institute, University of Helsinki, Finland

  6. 6

    University of Helsinki, Finland

  7. 7

    Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland, UK

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • viral meningo-encephalitis;
  • clinical involvement of central nervous system (CNS) - unusual manifestation of human viral infection;
  • encephalitis, presence of inflammatory process - in brain parenchyma associated with clinical evidence of brain dysfunction;
  • acute disseminated encephalomyelitis (ADEM) - or an infective process;
  • evidence classification scheme - for a diagnostic measure;
  • evidence classification scheme - for rating recommendations for a diagnostic measure;
  • diagnosis of viral encephalitis - febrile disease, accompanied by headache, altered level of consciousness, and symptoms and signs of cerebral dysfunction;
  • history, mandatory in assessment of patient - with suspected viral encephalitis;
  • acute disseminated encephalomyelitis;
  • techniques of immunocytochemistry (ICC), in situ hybridization (ISH) and PCR - profound impact on neuropathological diagnosis


This chapter contains sections titled:

  • Introduction

  • Methods

  • Definitions and scope

  • Clinical manifestations and relevant environmental and personal information

  • Diagnostic investigations

  • Other infective causes of meningoencephalitis and differential diagnosis

  • Therapy

  • References