Chapter 26. Treatment of Neuropathic Pain

  1. Nils Erik Gilhus MD, PhD Professor9,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director10 and
  3. Michael Brainin MD Professor11
  1. N. Attal1,2,
  2. G. Cruccu3,
  3. R. Baron4,
  4. M. Haanpää5,
  5. P. Hansson6,
  6. T. S. Jensen7 and
  7. T. Nurmikko8

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch26

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Treatment of Neuropathic Pain, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch26

Author Information

  1. 9

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 10

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 11

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    Hôpital Ambroise Paré, APHP, Boulogne - Billancourt, France

  2. 2

    Université Versailles - Saint - Quentin, Versailles, France

  3. 3

    La Sapienza University, Rome, Italy

  4. 4

    Universitatsklinikum Schleswig-Holstein, Kiel, Germany

  5. 5

    Helsinki University Hospital, Helsinki, Finland

  6. 6

    Karolinska Institutet/University Hospital, Stockholm, Sweden

  7. 7

    Aarhus University Hospital, Aarhus, Denmark

  8. 8

    University of Liverpool, UK

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • neurological problems - neuropathic pain treatment;
  • neuropathic pain (NP), causing lesion or disease of somatosensory system;
  • European Federation of Neurological Societies (EFNS) - first guidelines on pharmacological treatment of NP;
  • efficacy of tricyclic antidepressants (TCAs) - established in PPN (notably diabetic), based on single-centre Vlass I or II trials;
  • postherpetic neuralgia (PHN), common aftermath of herpes zoster in the elderly;
  • symptomatic TN - only small open-label Class IV studies - in symptomatic TN associated with multiple sclerosis;
  • classification of evidence for drug treatments - in less commonly studied NP conditions;
  • effects on pain symptoms and signs and predictors of response;
  • effects on quality of life, sleep and mood;
  • multi-aetiology NP, positive mainly for TCAs, opioids and cannabinoids


This chapter contains sections titled:

  • Background and objectives

  • Methods

  • Results

  • References