Chapter 27. Acute Relapses of Multiple Sclerosis

  1. Nils Erik Gilhus MD, PhD Professor9,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director10 and
  3. Michael Brainin MD Professor11
  1. F. Sellebjerg1,
  2. D. Barnes2,
  3. G. Filippini3,
  4. R. Midgard4,
  5. X. Montalban5,
  6. P. Rieckmann6,
  7. K. Selmaj7,
  8. L. H. Visser8 and
  9. P. Soelberg Sørensen1

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch27

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Acute Relapses of Multiple Sclerosis, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch27

Author Information

  1. 9

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 10

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 11

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    University of Copenhagen and Rigshospitalet, Copenhagen, Denmark

  2. 2

    Atkinson Morley's Hospital, Wimbledon, UK

  3. 3

    Fondazione Istituto Nazionale Neurologico C. Besta, Milan, Italy

  4. 4

    Molde Hospital, Norway

  5. 5

    University Hospital Vall d'Hebron, Barcelona, Spain

  6. 6

    University of British Columbia and Vancouver Coastal Health, Vancouver, British Columbia, Canada

  7. 7

    Medical University of Lodz, Poland

  8. 8

    St Elisabeth Hospital, Tilburg, The Netherlands

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • acute relapses of multiple sclerosis;
  • attacks or relapses, dominating feature of relapsing - remitting multiple sclerosis (MS);
  • glucocorticoid or ACTH treatment of MS relapses - analysed in Cochrane review;
  • specific glucocorticoids, dose and route of administration;
  • glucocorticoid treatment - of acute optic neuritis;
  • North American Optic Neuritis Treatment Trial (ONTT);
  • glucocorticoid treatment in MS subgroups;
  • side effects of glucocorticoid treatment;
  • patients with inflammatory demyelination - patients with MS, not responding to treatment with methylprednisolone may benefit from plasma exchange treatment;
  • intense, interdisciplinary rehabilitation programme - to be considered after treatment with i.v. methylprednisolone


This chapter contains sections titled:

  • Search strategy

  • Method for reaching consensus

  • Background

  • Results

  • References