Chapter 28. Status Epilepticus

  1. Nils Erik Gilhus MD, PhD Professor7,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director8 and
  3. Michael Brainin MD Professor9
  1. H. Meierkord1,
  2. P. Boon2,
  3. B. Engelsen3,
  4. K. Göcke4,
  5. S. Shorvon5,
  6. P. Tinuper6 and
  7. M. Holtkamp1

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch28

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Status Epilepticus, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch28

Author Information

  1. 7

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 8

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 9

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    Charité - Universitätsmedizin Berlin, Germany

  2. 2

    Ghent University Hospital, Belgium

  3. 3

    Haukeland University Hospital, and University of Bergen, Bergen, Norway

  4. 4

    Deutsche Epilepsievereinigung e.V., Berlin, Germany

  5. 5

    Institute of Neurology, University College London, UK

  6. 6

    University of Bologna, Italy

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • Status epilepticus (SE);
  • generalised convulsive and non-convulsive status epilepticus (GCSE, NCSE) - neurological conditions associated with significant mortality and morbidity rates;
  • initial treatment of generalised convulsive status epilepticus;
  • initial treatment of complex partial status epilepticus;
  • refractory generalised convulsive and non-convulsive SE;
  • Phenobarbital, assessed in initial anticonvulsant treatment of SE;
  • Levetiracetam, a second-generation antiepileptic drug - with proven oral efficacy in epilepsies with generalized and/or partial seizures;
  • anaesthetising anticonvulsants;
  • barbiturates, midazolam and propofol - commonly used in refractory SE (Class IV);
  • initial pharmacological treatment for GCSE and NCSE


This chapter contains sections titled:

  • Background

  • Search strategy

  • Methods for reaching consensus

  • Definitions

  • Results

  • References